Serum 25-Hydroxyvitamin D associated with indicators of body fat and insulin resistance in prepubertal chilean children

• Published in: International Journal of Obesity 2016-01, Vol.40 (1), p.147-152
• Main Authors: Cediel, G, Corvalán, C, Aguirre, C, de Romaña, D L, Uauy, R
• Format: Article
• Language: English
• Subjects: 692/308/174; 692/499; 692/53; 692/699/317; 692/700/1720; 82; 82/51; Adiposity; Age; Analysis; Body Composition; Body fat; Body Mass Index; Care and treatment; Child; Children; Children & youth; Chile - epidemiology; Cohort analysis; Epidemiology; Female; Follow-Up Studies; Food science; Health aspects; Health Promotion and Disease Prevention; Humans; Insulin Resistance; Internal Medicine; Longitudinal Studies; Male; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolism; Nutrition; Obesity; Obesity, Abdominal - blood; Obesity, Abdominal - epidemiology; Obesity, Abdominal - etiology; original-article; Public Health; Standard scores; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D Deficiency - blood; Vitamin D Deficiency - complications; Vitamin D Deficiency - epidemiology
• ISSN: 0307-0565; 1476-5497
• DOI: 10.1038/ijo.2015.148

Background: Consistent data on the relation between vitamin D, body fat and insulin resistance (IR) in children are lacking. Objectives: (1) To evaluate the association between serum 25-Hydroxyvitamin D [25(OH)D] and key indicators of: adiposity (total and central), IR, and (2) to estimate serum 25(OH)D cut-offs that best reflect IR and total and central adiposity in children. Subjects/Methods: Prepubertal children ( n =435, ~53% girls; ~age 7 years) from the Growth and Obesity Chilean Cohort Study were evaluated for potential associations between serum 25(OH)D and indicators of: (1) total adiposity (body mass index by age (BAZ), body fat (including three-component model)), central adiposity (waist circumference and trunk fatness); (2) IR (homeostasis model assessment of IR) and insulin sensitive (quantitative insulin sensitivity check index) using standardized multiple regression models with standardized coefficients and receiver operating characteristic curves. Results: Overall, mean serum 25(OH)D was 32.1±9.2 ng ml −1 , while 19.4% of children were obese (BAZ⩾2 s.d.). Serum 25(OH)D was inversely associated with indicators of total and central adiposity and with IR indicators. Effect sizes were moderate in girls (~0.3 for adiposity and IR indicators), while, weaker values were found in boys. Serum 25(OH)D estimated cut-offs that best predicted total, central adiposity and IR were~30 ng ml −1 . Children with suboptimal serum 25(OH)D (