In vivo evaluation of a simvastatin-loaded nanostructured lipid carrier for bone tissue regeneration

Alveolar bone loss has long been a challenge in clinical dental implant therapy. Simvastatin (SV) has been demonstrated to exert excellent anabolic effects on bone. However, the successful use of SV to increase bone formation in vivo largely depends on the local concentration of SV at the site of ac...

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Bibliographic Details
Published in:Nanotechnology 2016-03, Vol.27 (11), p.115708-115708
Main Authors: Yue, Xinxin, Niu, Mao, Zhang, Te, Wang, Cheng, Wang, Zhonglei, Wu, Wangxi, Zhang, Qi, Lai, Chunhua, Zhou, Lei
Format: Article
Language:English
Subjects:
Animals
Bone Diseases - pathology
Bone Diseases - therapy
Bone Regeneration - drug effects
Bones
Carriers
critical-sized bone defect
Delivery systems
Disease Models, Animal
Encapsulation
Formations
Humans
Lipids
Lipids - chemistry
Materials Testing
Nanostructure
nanostructured lipid carrier
Nanostructures - chemistry
Nanostructures - therapeutic use
osteogenesis
Rabbits
simvastatin
Simvastatin - administration & dosage
Simvastatin - chemistry
Simvastatin - pharmacology
Skull - injuries
Skull - pathology
Surgical implants
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Summary:Alveolar bone loss has long been a challenge in clinical dental implant therapy. Simvastatin (SV) has been demonstrated to exert excellent anabolic effects on bone. However, the successful use of SV to increase bone formation in vivo largely depends on the local concentration of SV at the site of action, and there have been continuing efforts to develop an appropriate delivery system. Specifically, nanostructured lipid carrier (NLC) systems have become a popular type of encapsulation carrier system. Therefore, SV-loaded NLCs (SNs) (179.4 nm in diameter) were fabricated in this study, and the osteogenic effect of the SNs was evaluated in a critical-sized rabbit calvarial defect. Our results revealed that the SNs significantly enhanced bone formation in vivo, as evaluated by hematoxylin and eosin (HE) staining, immunohistochemistry, and a fluorescence analysis. Thus, this novel nanostructured carrier system could be a potential encapsulation carrier system for SV in bone regeneration applications.
ISSN:0957-4484
1361-6528
DOI:10.1088/0957-4484/27/11/115708