Immunological subtypes analysis of Uygur diffuse large B-cell lymphoma in Xinjiang and their prognostic significance

This study aims to explore the application of Choi's typing method in the immunological typing of diffuse large B-cell lymphoma (DLBCL) in Xinjiang Autonomous Region and its prognostic significance. Seventy-eight cases of DLBCL tumor tissues from Xinjiang were collected to detect the expression...

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Bibliographic Details
Published in:Journal of cancer research and therapeutics 2015-10, Vol.11 (4), p.852-856
Main Authors: Jia, Cun-Dong, Liang, Li-Ping, Yang, Li-Li, Yue, Na, Zhao, Feng, Bai, Jing-Ping
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Analysis
Biomarkers, Tumor - metabolism
Care and treatment
Classification
Complications and side effects
Female
Gene expression
Germinal Center
Health aspects
Humans
Immunoenzyme Techniques
Immunohistochemistry
Immunology
Immunophenotyping - methods
Lymphatic system
Lymphocytic leukemia
Lymphoma
Lymphoma, Large B-Cell, Diffuse - classification
Lymphoma, Large B-Cell, Diffuse - diagnosis
Male
Medical prognosis
Metastasis
Methods
Middle Aged
Multivariate analysis
Neoplasm Staging
Prognosis
Studies
Survival Rate
Uighurs
Young Adult
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Summary:This study aims to explore the application of Choi's typing method in the immunological typing of diffuse large B-cell lymphoma (DLBCL) in Xinjiang Autonomous Region and its prognostic significance. Seventy-eight cases of DLBCL tumor tissues from Xinjiang were collected to detect the expression of germinal center B (GCB) cell-expressed transcript-1, FOXP1, CD10, bcl-6, and MUM1 using an immunohistochemical method. Then, immunological typing was carried out using Choi's typing method, and the survival analysis was performed using Kaplan-Meier method. Cox proportional hazard model was used to analyze the prognostic factors. GCB-cell-like-DLBCL and non-GCB-DLBCL accounting for 29.5% (23/78) and 70.5% (55/78), respectively. The 3-year overall survival of GCB-DLBCL was 58%, significantly higher than that of non-GCB-DLBCL (39%, P < 0.05). Multivariate analysis showed that International Prognostic Index and immunological typing were two independent prognostic factors for Uygur patients with DLBCL. Non-GCB-DLBCL is the main type of DLBCL in Xinjiang and Choi's typing method can be a helpful indicator to determine the prognosis of the Uygur DLBCL in Xinjiang.
ISSN:0973-1482
1998-4138
DOI:10.4103/0973-1482.144357