Neural activation-based sexual orientation and its correlation with free testosterone level in postoperative female-to-male transsexuals: preliminary study with 3.0-T fMRI

Purpose The purpose of this study was to evaluate the brain activation pattern associated with sexual orientation and its correlation with the level of the free testosterone (free T) in postoperative female-to-male (FtM) transsexuals using a 3.0-Tesla functional magnetic resonance imaging (fMRI). Ma...

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Bibliographic Details
Published in:Surgical and radiologic anatomy (English ed.) 2016-03, Vol.38 (2), p.245-252
Main Authors: Kim, Gwang-Won, Kim, Seok-Kwun, Jeong, Gwang-Woo
Format: Article
Language:English
Subjects:
Adult
Anatomy
Brain - diagnostic imaging
Brain - physiology
Female
Humans
Imaging
Magnetic Resonance Imaging
Male
Medicine & Public Health
Middle Aged
Neurobiology
NMR
Nuclear magnetic resonance
Orthopedics
Postoperative Period
Radiology
Sex Reassignment Surgery
Sexuality
Surgery
Testosterone
Testosterone - blood
Transgender persons
Transgender Persons - psychology
Transsexualism - blood
Transsexualism - psychology
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Summary:Purpose The purpose of this study was to evaluate the brain activation pattern associated with sexual orientation and its correlation with the level of the free testosterone (free T) in postoperative female-to-male (FtM) transsexuals using a 3.0-Tesla functional magnetic resonance imaging (fMRI). Materials and methods Eleven postoperative FtM transsexuals with sex reassignment surgery underwent fMRI on a 3.0-T MR scanner. Brain activity was measured while viewing erotic male and female nude pictures. Results The average level of free T in the FtM transsexuals was in the normal range of heterosexual men. The brain areas with predominant activities during viewing female nude pictures in contrast to male pictures included the hippocampus, parahippocampal gyrus, anterior cingulate gyrus, putamen, amygdala, hypothalamus, and insula ( p  
ISSN:0930-1038
1279-8517
DOI:10.1007/s00276-015-1547-z