Comparison of Autoimmune Thyroid Disease in Patients With Progressive and Stable Vitiligo

Background and Objective: Activity of vitiligo has not been considered as a patient selection criteria in previous studies; we decided to compare the presence of elevated thyroid auto-antibodies in patients with progressive and stable vitiligo. Methods: Seventy-two patients with vitiligo were examin...

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Bibliographic Details
Published in:Journal of cutaneous medicine and surgery 2016-03, Vol.20 (2), p.135-138
Main Authors: Yazdanpanah, Mohammad Javad, Seyedi Noghabi, Seyed Ali, Taghavi, Morteza, Afzal Aghaee, Monavar, Zabolinejad, Naghmeh
Format: Article
Language:English
Subjects:
Adult
Autoantibodies - immunology
Autoantigens - immunology
Case-Control Studies
Disease Progression
Female
Humans
Immunoglobulins
Iodide Peroxidase - immunology
Iron-Binding Proteins - immunology
Male
Prospective Studies
Thyroid gland
Thyroiditis, Autoimmune - complications
Thyroiditis, Autoimmune - diagnosis
Thyroiditis, Autoimmune - immunology
Thyrotropin - immunology
Vitiligo
Vitiligo - complications
Vitiligo - diagnosis
Vitiligo - immunology
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Summary:Background and Objective: Activity of vitiligo has not been considered as a patient selection criteria in previous studies; we decided to compare the presence of elevated thyroid auto-antibodies in patients with progressive and stable vitiligo. Methods: Seventy-two patients with vitiligo were examined for thyroid problems and were divided into 2 groups of stable and progressive vitiligo according to their history and physical examination. Anti-thyroid peroxidase antibodies (anti-TPO antibodies), thyroxine (T4), and thyroid stimulating hormone (TSH) levels were assessed for all patients. Results: Elevated levels of anti-TPO antibodies were observed in 43.7% of the patients with stable vitiligo and in 37.5% of patients with progressive vitiligo, which was not statistically significant (P = .315). Conclusion: This study not only confirmed thyroid dysfunction in patients with vitiligo but also showed that there was no difference in thyroid dysfunction and anti-TPO antibody levels in the subgroups of patients with stable or progressive vitiligo.
ISSN:1203-4754
1615-7109
DOI:10.1177/1203475415604551