Influence of dermal exposure to ultraviolet radiation and coal tar (polycyclic aromatic hydrocarbons) on the skin aging process

Highlights • We evaluate the Goeckerman therapy (GT) of psoriasis for skin aging process. • GT combines UV radiation and coal tar with polycyclic aromatic hydrocarbons (PAHs). • GT induces oxidative stress (oxidative damage DNA/RNA) and genotoxic damage. • UV radiation induces the vitamin D, which i...

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Bibliographic Details
Published in:Journal of dermatological science 2016-03, Vol.81 (3), p.192-202
Main Authors: Borska, Lenka, Andrys, Ctirad, Krejsek, Jan, Palicka, Vladimir, Vorisek, Viktor, Hamakova, Kvetoslava, Kremlacek, Jan, Borsky, Pavel, Fiala, Zdenek
Format: Article
Language:English
Subjects:
25-Hydroxy vitamin D
Administration, Cutaneous
Adult
Aged
Biomarkers - blood
Biomarkers - urine
Chromosomal aberration
Chronic Disease
Coal Tar - administration & dosage
Coal Tar - adverse effects
Combined Modality Therapy
Dermatology
DNA Damage
Female
Humans
Keratolytic Agents - administration & dosage
Keratolytic Agents - adverse effects
Male
Middle Aged
Oxidative stress
Oxidative Stress - drug effects
Oxidative Stress - radiation effects
Polycyclic aromatic hydrocarbons
Polycyclic Aromatic Hydrocarbons - administration & dosage
Polycyclic Aromatic Hydrocarbons - adverse effects
Psoriasis - diagnosis
Psoriasis - metabolism
Psoriasis - therapy
Pyrenes - urine
RNA Stability - drug effects
RNA Stability - radiation effects
Skin Aging - drug effects
Skin Aging - radiation effects
Smoking - adverse effects
Time Factors
Treatment Outcome
Ultraviolet Therapy - adverse effects
Ultraviolet Therapy - methods
UV radiation
Vitamin D - analogs & derivatives
Vitamin D - blood
Whole-Body Irradiation
Young Adult
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Summary:Highlights • We evaluate the Goeckerman therapy (GT) of psoriasis for skin aging process. • GT combines UV radiation and coal tar with polycyclic aromatic hydrocarbons (PAHs). • GT induces oxidative stress (oxidative damage DNA/RNA) and genotoxic damage. • UV radiation induces the vitamin D, which is protective factor of the aging process. • Vitamin D correlates with oxidative stress and time of UV radiation exposure.
ISSN:0923-1811
1873-569X
DOI:10.1016/j.jdermsci.2015.12.010