Is disulphide/thiol ratio related to blood pressure in masked hypertension?

Dynamic thiol/disulphide homeostasis plays a critical role in numerous intracellular enzymatic pathways including antioxidant defence and detoxification. In this study, we sought to investigate dynamic thiol/disulphide homeostasis in patients with masked hypertension (MHT) and its relationship with...

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Bibliographic Details
Published in:Clinical and experimental hypertension (1993) 2016-02, Vol.38 (2), p.150-154
Main Authors: Ateş, İhsan, Ozkayar, Nihal, Altay, Mustafa, Yilmaz, Fatma Meriç, Topçuoğlu, Canan, Alışık, Murat, Erel, Özcan, Dede, Fatih
Format: Article
Language:English
Subjects:
Adult
Blood Pressure - physiology
Blood Pressure Determination
Case-Control Studies
Disulfides - blood
Dynamic thiol/disulphide
Female
Homeostasis
Humans
isolated ambulatory hypertension
Male
Masked Hypertension - blood
Masked Hypertension - diagnosis
Masked Hypertension - physiopathology
Middle Aged
oxidant radicals
oxidative stress
oxidised thiol
Prospective Studies
Risk Factors
Sulfhydryl Compounds - blood
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Summary:Dynamic thiol/disulphide homeostasis plays a critical role in numerous intracellular enzymatic pathways including antioxidant defence and detoxification. In this study, we sought to investigate dynamic thiol/disulphide homeostasis in patients with masked hypertension (MHT) and its relationship with blood pressure. Forty patients (23 men, 17 women) with newly diagnosed MHT and not yet on medical therapy, and 40 healthy volunteers (21 men, 19 women) were enrolled. Blood thiol/disulphide homeostasis was measured in both groups. Serum native and total thiol levels were measured using the novel, fully automated colorimetric method developed by Erel et al. Serum disulphide level was calculated as (serum total thiol − serum native thiol)/2. Native and total thiol levels (p = 0.001) and native thiol/total thiol ratio (p = 0.023) were found to be lower in patients with MHT when compared to those of the control group. Disulphide level and ratios of disulphide/native thiol and disulphide/total thiol were higher in patients with MHT than in the control group (p = 0.001). A positive correlation of systolic blood pressure (SBP) and diastolic blood pressure (DBP) was observed with disulphide/native thiol ratio (p 
ISSN:1064-1963
1525-6006
DOI:10.3109/10641963.2015.1060995