Diffusion-weighted MR imaging of pancreatic cancer and inflammation: Prognostic significance of pancreatic inflammation in pancreatic cancer patients

Abstract Background Pancreatic cancer often accompanies chronic obstructive pancreatitis (COP) due to obstruction of the main pancreatic duct, and the inflammatory environment may enhance cancer progression. The purpose of this study is to evaluate COP using the apparent diffusion coefficient (ADC)...

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Bibliographic Details
Published in:Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2016-01, Vol.16 (1), p.121-126
Main Authors: Hayano, Koichi, Miura, Fumihiko, Wada, Keita, Suzuki, Kazufumi, Takeshita, Koji, Amano, Hodaka, Toyota, Naoyuki, Sano, Keiji, Asano, Takehide
Format: Article
Language:English
Subjects:
Adenocarcinoma - diagnostic imaging
Adenocarcinoma - pathology
Adult
Aged
Aged, 80 and over
Apparent diffusion coefficient
Cancer therapies
Diffusion
Diffusion-weighted imaging
Endocrinology & Metabolism
Female
Gastroenterology and Hepatology
Humans
Inflammation
Inflammation - diagnostic imaging
Inflammation - pathology
Magnetic Resonance Imaging
Male
Medical prognosis
Metastasis
Middle Aged
Multivariate Analysis
Pancreatic cancer
Pancreatic Neoplasms - diagnostic imaging
Pancreatic Neoplasms - pathology
Pancreatitis
Prostate cancer
Retrospective Studies
Studies
Surgery
Survival
Veins & arteries
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Summary:Abstract Background Pancreatic cancer often accompanies chronic obstructive pancreatitis (COP) due to obstruction of the main pancreatic duct, and the inflammatory environment may enhance cancer progression. The purpose of this study is to evaluate COP using the apparent diffusion coefficient (ADC) value measured by diffusion-weighted MR imaging (DWI), and to assess its prognostic significance in pancreatic cancer. Methods Twenty-eight patients (16 men, 12 women; mean age 67.1 years) with pancreatic cancers who underwent DWI followed by curative surgery were evaluated. The ADC value of pancreatic parenchyma upstream to the tumor (upstream pancreas) was measured and compared with the upstream pancreatic duct dilatation to assess whether DWI could reflect COP. The ADC values of tumor and upstream portion were compared with overall survival (OS) using Cox regression and Kaplan–Meier analysis. Results The ADC value of upstream pancreas was significantly lower in patients with greater dilated pancreatic duct than those with less (P = 0.03). In univariate Cox regression analysis, the ADC value of upstream pancreas showed a significant association with OS (P = 0.01), but that of tumor did not (P = 0.06). In Kaplan–Meier analysis, patients with lower ADC value of upstream pancreas (
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2015.10.004