Impact of Delftia tsuruhatensis and Achromobacter xylosoxidans on Escherichia coli dual-species biofilms treated with antibiotic agents

Recently it was demonstrated that for urinary tract infections species with a lower or unproven pathogenic potential, such as Delftia tsuruhatensis and Achromobacter xylosoxidans, might interact with conventional pathogenic agents such as Escherichia coli. Here, single- and dual-species biofilms of...

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Bibliographic Details
Published in:Biofouling (Chur, Switzerland) Switzerland), 2016-03, Vol.32 (3), p.227-241
Main Authors: Azevedo, Andreia S., Almeida, Carina, Pereira, Bruno, Melo, Luís F., Azevedo, Nuno F.
Format: Article
Language:English
Subjects:
Achromobacter denitrificans - drug effects
Achromobacter denitrificans - physiology
Achromobacter xylosoxidans
Anti-Bacterial Agents - pharmacology
Antibiotics
Antiinfectives and antibacterials
Biofilms
Biofilms - drug effects
Biofilms - growth & development
catheter-associated urinary tract infections
Catheter-Related Infections - drug therapy
Catheter-Related Infections - microbiology
Consortia
Delftia - drug effects
Delftia - physiology
Escherichia coli
Escherichia coli - drug effects
Escherichia coli - physiology
Fitness
Humans
LNA/2′OMe-FISH
Microbial Interactions - drug effects
Microbial Interactions - physiology
Microorganisms
Multispecies biofilms
Tolerances
uncommon species
Urinary Catheters - adverse effects
Urinary Catheters - microbiology
Urinary Tract Infections - drug therapy
Urinary Tract Infections - microbiology
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Summary:Recently it was demonstrated that for urinary tract infections species with a lower or unproven pathogenic potential, such as Delftia tsuruhatensis and Achromobacter xylosoxidans, might interact with conventional pathogenic agents such as Escherichia coli. Here, single- and dual-species biofilms of these microorganisms were characterized in terms of microbial composition over time, the average fitness of E. coli, the spatial organization and the biofilm antimicrobial profile. The results revealed a positive impact of these species on the fitness of E. coli and a greater tolerance to the antibiotic agents. In dual-species biofilms exposed to antibiotics, E. coli was able to dominate the microbial consortia in spite of being the most sensitive strain. This is the first study demonstrating the protective effect of less common species over E. coli under adverse conditions imposed by the use of antibiotic agents.
ISSN:0892-7014
1029-2454
DOI:10.1080/08927014.2015.1124096