NF-κB transcription factors: critical regulators of hematopoiesis and neuronal survival

The Rel/NF-κB family of transcription factors has been implicated in the regulation of genes involved in immune and inflammatory responses, and of processes such as cell survival, apoptosis, development, differentiation, cell growth and neoplastic transformation. In this report we will summarize rec...

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Bibliographic Details
Published in:Cytokine & growth factor reviews 2000-12, Vol.11 (4), p.303-320
Main Authors: Denk, Andrea, Wirth, Thomas, Baumann, Bernd
Format: Article
Language:English
Subjects:
Apoptosis
Hematopoiesis
Neuronal survival
NF-^KB protein
NF-κB
Signal transduction
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Summary:The Rel/NF-κB family of transcription factors has been implicated in the regulation of genes involved in immune and inflammatory responses, and of processes such as cell survival, apoptosis, development, differentiation, cell growth and neoplastic transformation. In this report we will summarize recent findings which highlight critical roles of NF-κB in different processes in hematopoietic and neuronal cells.
ISSN:1359-6101
DOI:10.1016/S1359-6101(00)00009-5