Gonadotropin-Releasing Hormone Analog Therapy Failed to Improve Predicted Final Height in Two Children with Central Precocious Puberty and Microcephalus

Long-acting gonadotropin-releasing hormone (GnRH) analog treatment for central precocious puberty (CPP) suppresses excessive bone maturation by inhibiting the pituitary-gonadal axis, and usually assures favorable results for growth potential. Recently, we encountered two children with CPP and microc...

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Bibliographic Details
Published in:Endocrine Journal 2000, Vol.47(SupplMarch), pp.S129-S132
Main Authors: OKUHARA, KOJI, TAJIMA, TOSHIHIRO, ABE, SHUJI, SATOH, KOHEI, NAKAE, JUN, SHINOHARA, NOZOMI, FUJIEDA, KENJI
Format: Article
Language:English
Subjects:
Adolescent
Body Height - drug effects
Central precocious puberty
Child, Preschool
Female
Forecasting
GnRH analog
Gonadotropin-Releasing Hormone - analogs & derivatives
Humans
Male
Microcephalus
Microcephaly - complications
Puberty, Precocious - complications
Puberty, Precocious - drug therapy
Treatment Failure
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Summary:Long-acting gonadotropin-releasing hormone (GnRH) analog treatment for central precocious puberty (CPP) suppresses excessive bone maturation by inhibiting the pituitary-gonadal axis, and usually assures favorable results for growth potential. Recently, we encountered two children with CPP and microcephalus in whom GnRH analog therapy arrested pubertal development, but could not suppress bone age maturation effectively. Eventually, their final height deteriorated rather than improved. The reason why these two cases did not respond to GnRH analog therapy remains unknown. However, microcephalus and minor cerebral anomalies may have some links to deterioration of final height. Our cases suggest that careful evaluation will be required especially for CPP with microcephalus throughout treatment with GnRH analog.
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.47.SupplMarch_S129