Short-Wavelength Automated Perimetry Parameters at Baseline and Following Remission in Patients With Birdshot Retinochoroidopathy

• Published in: American journal of ophthalmology 2016-03, Vol.163, p.83-92.e6
• Main Authors: Maleki, Arash, Swan, Robert T, Silpa-Archa, Sukhum, Preble, Janine M, He, Yuchen, Foster, C. Stephen
• Format: Article
• Language: English
• Subjects: Adult; Aged; Automation; Chorioretinitis - diagnosis; Chorioretinitis - drug therapy; Chorioretinitis - physiopathology; Coloring Agents - administration & dosage; Drug Implants; Electroretinography; Female; Field study; Fluocinolone Acetonide - administration & dosage; Fluorescein Angiography; Glaucoma; Glucocorticoids - administration & dosage; Humans; Indocyanine Green - administration & dosage; Inflammation; Intraocular Pressure; Male; Medical imaging; Middle Aged; Ophthalmology; Optic nerve; Patients; Retrospective Studies; Standard deviation; Vision Disorders - diagnosis; Vision Disorders - drug therapy; Vision Disorders - physiopathology; Visual Acuity - physiology; Visual Field Tests; Visual Fields - physiology
• ISSN: 0002-9394; 1879-1891
• DOI: 10.1016/j.ajo.2015.11.024

Purpose To identify changes in short-wavelength automated perimetry patterns and parameters between the active and inactive states. Design Retrospective cohort study with age-matched, normal controls. Methods setting : Private tertiary referral center. study population : Seventy-five eyes of 38 patients with active birdshot retinochoroidopathy and 37 eyes of 37 historical normal controls. intervention : Thirty-seven patients received immunomodulatory therapy. A fluocinolone acetonide intravitreal implant (Retisert) was implanted in both eyes of 1 patient as an initial treatment. main outcome measures : Changes in short-wavelength automated perimetry total deviation scores, pattern deviation scores, mean deviation, and pattern standard deviation in the active phase and the remission state. Results Mean deviation ( P  = .006), pattern standard deviation ( P  = .001), total deviation score ( P  = .002), and pattern deviation score ( P  = .007) were significantly different from the active phase to the remission state. The length of time required to achieve remission did not significantly affect the changes in mean deviation (regression coefficient = 0.01; P  = .92), pattern standard deviation (regression coefficient = 0.01; P  = .87), total deviation score (regression coefficient = −0.1; P  = .32), or pattern deviation score (regression coefficient = 0.1; P  = .36) from the active phase to the remission state. Conclusion There was significant improvement in total deviation score, pattern deviation score, mean deviation, and pattern standard deviation on short-wavelength automated perimetry as patients achieved remission. Short-wavelength automated perimetry appears to be a useful and complementary modality in monitoring disease activity in birdshot retinochoroidopathy.