The Characteristics of Bone Metastasis in Patients with Colorectal Cancer: A Long-Term Report from a Single Institution

Background Bone metastasis in patients with colorectal cancer (CRC) is very rare, and data are extremely lacking. We aimed to evaluate the characteristics of bone metastasis in patients with CRC. Materials and methods We performed a chart review of 63 patients (1.1 %) with bone metastasis among 5479...

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Bibliographic Details
Published in:World journal of surgery 2016-04, Vol.40 (4), p.982-986
Main Authors: Baek, Se-Jin, Hur, Hyuk, Min, Byung-Soh, Baik, Seung-Hyuk, Lee, Kang-Young, Kim, Nam-Kyu
Format: Article
Language:English
Subjects:
Abdominal Surgery
Bone Metastasis
Bone Neoplasms - diagnosis
Bone Neoplasms - mortality
Bone Neoplasms - secondary
Bone Pain
Cardiac Surgery
Colorectal Cancer
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Female
Follow-Up Studies
General Surgery
Humans
Magnetic Resonance Imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Staging
Original Scientific Report
Pamidronate
Positron-Emission Tomography
Prognosis
Republic of Korea - epidemiology
Risk Factors
Surgery
Survival Rate - trends
Thoracic Surgery
Time Factors
Tomography, X-Ray Computed
Vascular Surgery
Zoledronic Acid
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Summary:Background Bone metastasis in patients with colorectal cancer (CRC) is very rare, and data are extremely lacking. We aimed to evaluate the characteristics of bone metastasis in patients with CRC. Materials and methods We performed a chart review of 63 patients (1.1 %) with bone metastasis among 5479 patients who underwent surgery for CRC. Results Most patients were stage 3 (17.5 %) or 4 (73.0 %), and 32 patients (50.8 %) were diagnosed with bone metastasis at initial diagnoses of CRC. Thirty-one patients developed bone metastasis during the follow-up period with median 10.1-month interval. PET–CT was most frequently used for the diagnosis of bone metastasis (71.4 %), and the spine was the most commonly involved site (77.8 %). Most patients had multiple bone metastases (73.0 %) and other metastases (87.3 %). Bone pain was the most common skeletal-related event (25.4 %), and patients were treated with radiation (25.4 %), surgery (14.3 %), or bisphosphonate (6.3 %). The median survival time was 17.8 months, and the 5-year survival rate was 5.7 %. In the multivariate analysis, the risk factors for survival included initial bone metastasis (hazard ratio [HR] 3.03; P  
ISSN:0364-2313
1432-2323
DOI:10.1007/s00268-015-3296-x