(68)Ga-Pentixafor-PET/CT for Imaging of Chemokine Receptor 4 Expression in Glioblastoma

Chemokine receptor-4 (CXCR4) has been reported to be overexpressed in glioblastoma (GBM) and to be associated with poor survival. This study investigated the feasibility of non-invasive CXCR4-directed imaging with positron emission tomography/computed tomography (PET/CT) using the radiolabelled chem...

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Bibliographic Details
Published in:Theranostics 2016, Vol.6 (3), p.428-434
Main Authors: Lapa, Constantin, Lückerath, Katharina, Kleinlein, Irene, Monoranu, Camelia Maria, Linsenmann, Thomas, Kessler, Almuth F, Rudelius, Martina, Kropf, Saskia, Buck, Andreas K, Ernestus, Ralf-Ingo, Wester, Hans-Jürgen, Löhr, Mario, Herrmann, Ken
Format: Article
Language:English
Subjects:
Adult
Aged
Coordination Complexes - administration & dosage
Glioblastoma - diagnostic imaging
Glioblastoma - pathology
Glioblastoma - surgery
Humans
Male
Middle Aged
Peptides, Cyclic - administration & dosage
Pilot Projects
Positron-Emission Tomography - methods
Receptors, CXCR4 - analysis
Tomography - methods
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Summary:Chemokine receptor-4 (CXCR4) has been reported to be overexpressed in glioblastoma (GBM) and to be associated with poor survival. This study investigated the feasibility of non-invasive CXCR4-directed imaging with positron emission tomography/computed tomography (PET/CT) using the radiolabelled chemokine receptor ligand (68)Ga-Pentixafor. 15 patients with clinical suspicion on primary or recurrent glioblastoma (13 primary, 2 recurrent tumors) underwent (68)Ga-Pentixafor-PET/CT for assessment of CXCR4 expression prior to surgery. O-(2-(18)F-fluoroethyl)-L-tyrosine ((18)F-FET) PET/CT images were available in 11/15 cases and were compared visually and semi-quantitatively (SUVmax, SUVmean). Tumor-to-background ratios (TBR) were calculated for both PET probes. (68)Ga-Pentixafor-PET/CT results were also compared to histological CXCR4 expression on neuronavigated surgical samples. (68)Ga-Pentixafor-PET/CT was visually positive in 13/15 cases with SUVmean and SUVmax of 3.0±1.5 and 3.9±2.0 respectively. Respective values for (18)F-FET were 4.4±2.0 (SUVmean) and 5.3±2.3 (SUVmax). TBR for SUVmean and SUVmax were higher for (68)Ga-Pentixafor than for (18)F-FET (SUVmean 154.0±90.7 vs. 4.1±1.3; SUVmax 70.3±44.0 and 3.8±1.2, p
ISSN:1838-7640
DOI:10.7150/thno.13986