Intraductal papillary mucinous neoplasm of the pancreas, one manifestation of a more systemic disease?

Abstract Background Several studies have demonstrated a high prevalence of extrapancreatic malignancies, and an association with autoimmune pancreatitis in patients with intraductal papillary mucinous neoplasm (IPMN). We hypothesized that IPMNs were associated with an increase rate of systemic disea...

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Bibliographic Details
Published in:The American journal of surgery 2016-03, Vol.211 (3), p.512-518
Main Authors: Roch, Alexandra M., M.D., M.S, Rosati, Carlo Maria, M.D, Cioffi, Jessica L., M.D, Ceppa, Eugene P., M.D, DeWitt, John M., M.D, Al-Haddad, Mohammad A., M.D, House, Michael G., M.D, Zyromski, Nicholas J., M.D, Nakeeb, Attila, M.D, Schmidt, C. Max, M.D., Ph.D., M.B.A
Format: Article
Language:English
Subjects:
Adenocarcinoma, Mucinous - epidemiology
Adenocarcinoma, Mucinous - pathology
Adenocarcinoma, Mucinous - surgery
Adult
Aged
Aged, 80 and over
Autoimmune diseases
Autoimmune Diseases - epidemiology
Autoimmune Diseases - pathology
Biomarkers
Cancer
Carcinoma, Pancreatic Ductal - epidemiology
Carcinoma, Pancreatic Ductal - pathology
Carcinoma, Pancreatic Ductal - surgery
Carcinoma, Papillary - epidemiology
Carcinoma, Papillary - pathology
Carcinoma, Papillary - surgery
Disease
Endoscopy
Epidemiology
Extrapancreatic malignancies
Female
Health surveillance
Humans
Incidence
Intraductal papillary mucinous neoplasm
Medical imaging
Middle Aged
Mortality
Neoplasms, Multiple Primary - epidemiology
Neoplasms, Multiple Primary - pathology
Pancreas
Pathology
Public health
Retrospective Studies
Studies
Surgery
Tumors
Ultrasonic imaging
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Summary:Abstract Background Several studies have demonstrated a high prevalence of extrapancreatic malignancies, and an association with autoimmune pancreatitis in patients with intraductal papillary mucinous neoplasm (IPMN). We hypothesized that IPMNs were associated with an increase rate of systemic diseases. Methods From 1996 to 2013, a retrospective analysis of a prospectively collected database was performed and supplemented with electronic medical charts review. Results Two hundred twenty extrapancreatic malignancies were found in 185 patients (22%) compared with expected 5% in the general population. Colorectal, lung, and renal cell carcinoma had significant observed/expected ratios ( P < .0001). One hundred ten synchronous autoimmune diseases were found in 96 patients (11%). Systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease showed statistically significant observed/expected ratios ( P < .0001, .01, and
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2015.12.009