Hyaluronic acid modified mesoporous carbon nanoparticles for targeted drug delivery to CD44-overexpressing cancer cells

In this paper, hyaluronic acid (HA) functionalized uniform mesoporous carbon spheres (UMCS) were synthesized for targeted enzyme responsive drug delivery using a facile electrostatic attraction strategy. This HA modification ensured stable drug encapsulation in mesoporous carbon nanoparticles in an...

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Bibliographic Details
Published in:Nanotechnology 2016-04, Vol.27 (13), p.135102-135112
Main Authors: Wan, Long, Jiao, Jian, Cui, Yu, Guo, Jingwen, Han, Ning, Di, Donghua, Chang, Di, Wang, Pu, Jiang, Tongying, Wang, Siling
Format: Article
Language:English
Subjects:
Animals
Cancer
Carbon
Cell Survival - drug effects
co-delivery
Colorectal Neoplasms - drug therapy
controlled release
Doxorubicin - administration & dosage
Doxorubicin - chemistry
Doxorubicin - pharmacology
Drug Delivery Systems
Drugs
HCT116 Cells
Humans
Hyaluronan Receptors - metabolism
Hyaluronic acid
Hyaluronic Acid - chemical synthesis
mesoporous carbon nanoparticles
Mice
Mice, Nude
Nanoparticles
Nanoparticles - administration & dosage
Nanoparticles - chemistry
Porosity
Receptors
Tumors
Verapamil - administration & dosage
Verapamil - chemistry
Verapamil - pharmacology
Xenograft Model Antitumor Assays
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Summary:In this paper, hyaluronic acid (HA) functionalized uniform mesoporous carbon spheres (UMCS) were synthesized for targeted enzyme responsive drug delivery using a facile electrostatic attraction strategy. This HA modification ensured stable drug encapsulation in mesoporous carbon nanoparticles in an extracellular environment while increasing colloidal stability, biocompatibility, cell-targeting ability, and controlled cargo release. The cellular uptake experiments of fluorescently labeled mesoporous carbon nanoparticles, with or without HA functionalization, demonstrated that HA-UMCS are able to specifically target cancer cells overexpressing CD44 receptors. Moreover, the cargo loaded doxorubicin (DOX) and verapamil (VER) exhibited a dual pH and hyaluronidase-1 responsive release in the tumor microenvironment. In addition, VER/DOX/HA-UMCS exhibited a superior therapeutic effect on an in vivo HCT-116 tumor in BALB/c nude mice. In summary, it is expected that HA-UMCS will offer a new method for targeted co-delivery of drugs to tumors overexpressing CD44 receptors.
ISSN:0957-4484
1361-6528
DOI:10.1088/0957-4484/27/13/135102