An unusual finding of massive pulmonary embolism in a patient during treatment with high-dose ibuprofen

Non-steroidal anti-inflammatory drugs have been associated with an increased risk of venous thromboembolism. We report for the first time, the case of a patient who developed massive pulmonary embolism after a long period of treatment with high doses of ibuprofen. A 65-year-old woman was admitted wi...

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Bibliographic Details
Published in:Aging clinical and experimental research 2016-02, Vol.28 (1), p.167-168
Main Authors: Bilora, Franca, Adamo, Angelo, Pomerri, Fabio, Prandoni, Paolo
Format: Article
Language:English
Subjects:
Aged
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Anticoagulants - administration & dosage
Case Report
Embolisms
Female
Geriatrics/Gerontology
Health risk assessment
Heparin, Low-Molecular-Weight - administration & dosage
Humans
Ibuprofen - administration & dosage
Ibuprofen - adverse effects
Long Term Adverse Effects - prevention & control
Medicine
Medicine & Public Health
Nonsteroidal anti-inflammatory drugs
Osteoarthritis, Spine - drug therapy
Pulmonary Embolism - diagnosis
Pulmonary Embolism - drug therapy
Pulmonary Embolism - etiology
Pulmonary Embolism - physiopathology
Pulmonary embolisms
Rivaroxaban - administration & dosage
Thromboembolism
Tomography, Spiral Computed - methods
Treatment Outcome
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Summary:Non-steroidal anti-inflammatory drugs have been associated with an increased risk of venous thromboembolism. We report for the first time, the case of a patient who developed massive pulmonary embolism after a long period of treatment with high doses of ibuprofen. A 65-year-old woman was admitted with severe dyspnea while on treatment with high doses of ibuprofen for diffuse spine pain due to arthrosis. A spiral computed tomography showed a massive pulmonary embolism. No other explanation for the thromboembolic disorder was found. She was successfully treated with therapeutic doses of low-molecular-weight heparin followed by rivaroxaban. Ibuprofen was discontinued and replaced by tramadol. High-dose ibuprofen is likely to have accounted for the life-threatening thromboembolic disorder.
ISSN:1720-8319
1594-0667
1720-8319
DOI:10.1007/s40520-015-0467-4