Prognostic Impacts of Metabolic Syndrome in Patients With Chronic Heart Failure　– A Multicenter Prospective Cohort Study

Background:Metabolic syndrome (MetS) is involved in the increased risk of atherosclerotic cardiovascular diseases. We have previously reported that the prevalence of MetS is more than 2-fold greater in patients with chronic heart failure (CHF) than in the general population in Japan. However, the pr...

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Bibliographic Details
Published in:Circulation Journal 2016/02/25, Vol.80(3), pp.677-688
Main Authors: Tadaki, Soichiro, Sakata, Yasuhiko, Miura, Yutaka, Miyata, Satoshi, Asakura, Masanori, Shimada, Kazunori, Yamamoto, Takeshi, Fukumoto, Yoshihiro, Kadokami, Toshiaki, Yasuda, Satoshi, Miura, Toshiro, Ando, Shin-ichi, Yano, Masafumi, Kitakaze, Masafumi, Daida, Hiroyuki, Shimokawa, Hiroaki
Format: Article
Language:English
Subjects:
Aged
Chronic Disease
Chronic heart failure
Female
Heart Failure - blood
Heart Failure - diagnosis
Heart Failure - epidemiology
Heart Failure - etiology
Humans
Male
Metabolic syndrome
Metabolic Syndrome - blood
Metabolic Syndrome - diagnosis
Metabolic Syndrome - epidemiology
Obesity
Obesity - blood
Obesity - complications
Obesity - diagnosis
Obesity - epidemiology
Prevalence
Prognosis
Prospective Studies
Sex differences
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Summary:Background:Metabolic syndrome (MetS) is involved in the increased risk of atherosclerotic cardiovascular diseases. We have previously reported that the prevalence of MetS is more than 2-fold greater in patients with chronic heart failure (CHF) than in the general population in Japan. However, the prognostic impact of MetS in CHF patients remains to be elucidated.Methods and Results:In the present nationwide, large-scale clinical study in Japan, we enrolled 4,762 patients with Stage C/D CHF. The prevalence of MetS by the definition of the Japanese Committee for the Diagnostic Criteria in 2005 was 41.3% (50.6% in males, 21.5% in females). MetS was characterized by higher prevalence of males, obesity and lifestyle-related comorbidities, including glucose intolerance, dyslipidemia and hypertension. Multivariate Cox hazard analysis showed that MetS was associated with increased incidence of the composite of all-cause death and atherosclerotic events in males (hazard ratio [HR] 1.28; 95% confidence interval [CI] 1.06–1.54, P=0.011) but not in females (HR 1.23, 95% CI 0.87–1.75, P=0.241). Among the components of MetS, over waist circumference and glucose intolerance were significantly associated with increased incidence of the composite endpoint (HR 1.23, P=0.038, and HR 1.29, P
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.CJ-15-0942