Surface display of a borrelial lipoprotein on meningococcal outer membrane vesicles

Highlights • Borrelial lipoprotein OspA loses its outer-surface localization in Neisseria. • Surface-display rescued by fusion to part of meningococcal surface-lipoprotein fHbp. • OMVs with surface-exposed OspA elicit OspA-specific antibody responses in mice. • New method for surface display of hete...

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Published in:Vaccine 2016-02, Vol.34 (8), p.1025-1033
Main Authors: Salverda, Merijn L.M, Meinderts, Sanne M, Hamstra, Hendrik-Jan, Wagemakers, Alex, Hovius, Joppe W.R, van der Ark, Arno, Stork, Michiel, van der Ley, Peter
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antibodies, Bacterial - blood
Antigens
Antigens, Bacterial - immunology
Antigens, Surface - immunology
Bacteria
Bacterial Outer Membrane Proteins - immunology
Bacterial Proteins - immunology
Bacterial Vaccines - immunology
Bacteriology
Borrelia burgdorferi
Cloning
Conflicts of interest
Deoxyribonucleic acid
DNA
Female
fHbp
Gram-negative bacteria
Heterologous expression
Immune response
Immunization
Lipoprotein
Lipoproteins
Lipoproteins - immunology
Localization
Meningitis
Mice
Mice, Inbred BALB C
Neisseria meningitidis
Neisseria meningitidis - immunology
OMV
OspA
Outer Membrane Vesicles
Proteins
Surface display
Vaccines
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container_issue 8
container_start_page 1025
container_title Vaccine
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creator Salverda, Merijn L.M
Meinderts, Sanne M
Hamstra, Hendrik-Jan
Wagemakers, Alex
Hovius, Joppe W.R
van der Ark, Arno
Stork, Michiel
van der Ley, Peter
description Highlights • Borrelial lipoprotein OspA loses its outer-surface localization in Neisseria. • Surface-display rescued by fusion to part of meningococcal surface-lipoprotein fHbp. • OMVs with surface-exposed OspA elicit OspA-specific antibody responses in mice. • New method for surface display of heterologous lipoproteins in OMVs.
doi_str_mv 10.1016/j.vaccine.2016.01.019
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identifier ISSN: 0264-410X
ispartof Vaccine, 2016-02, Vol.34 (8), p.1025-1033
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source ScienceDirect Freedom Collection
subjects Allergy and Immunology
Animals
Antibodies, Bacterial - blood
Antigens
Antigens, Bacterial - immunology
Antigens, Surface - immunology
Bacteria
Bacterial Outer Membrane Proteins - immunology
Bacterial Proteins - immunology
Bacterial Vaccines - immunology
Bacteriology
Borrelia burgdorferi
Cloning
Conflicts of interest
Deoxyribonucleic acid
DNA
Female
fHbp
Gram-negative bacteria
Heterologous expression
Immune response
Immunization
Lipoprotein
Lipoproteins
Lipoproteins - immunology
Localization
Meningitis
Mice
Mice, Inbred BALB C
Neisseria meningitidis
Neisseria meningitidis - immunology
OMV
OspA
Outer Membrane Vesicles
Proteins
Surface display
Vaccines
title Surface display of a borrelial lipoprotein on meningococcal outer membrane vesicles
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