Distribution of semduramicin in hen eggs and tissues after administration of cross-contaminated feed

Semduramicin is an ionophore coccidiostat used in the poultry industry as a feed additive. Cross-contamination of feeds for non-target animals with semduramicin is unavoidable. However, it is not known whether undesirable residues of semduramicin may occur in food after cross-contaminated feed is ad...

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Bibliographic Details
Published in:Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment Chemistry, analysis, control, exposure & risk assessment, 2014, Vol.31 (8), p.1393-1398
Main Authors: Olejnik, Małgorzata, Szprengier-Juszkiewicz, Teresa, Jedziniak, Piotr
Format: Article
Language:English
Subjects:
Additives
Animals
Biological and medical sciences
Chickens
Coccidiostats - analysis
Coccidiostats - pharmacokinetics
Contamination
cross contamination
distribution
drug residues
Drug Residues - analysis
Drug Residues - pharmacokinetics
egg yolk
eggs
Eggs - analysis
feed additives
feed contamination
feed cross-contamination
feed industry
Feeds
Female
Food Contamination
Food industries
Fundamental and applied biological sciences. Psychology
gizzard
hens
hydrophobicity
liver
muscles
Nigericin - analogs & derivatives
Nigericin - analysis
Nigericin - pharmacokinetics
Poultry
poultry industry
residues
semduramicin
spleen
Tissue Distribution
tissues
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Summary:Semduramicin is an ionophore coccidiostat used in the poultry industry as a feed additive. Cross-contamination of feeds for non-target animals with semduramicin is unavoidable. However, it is not known whether undesirable residues of semduramicin may occur in food after cross-contaminated feed is administered to animals. The aim of the work was to determine the levels of semduramicin in hen eggs (yolks and albumen) and tissues (liver, muscle, spleen, gizzard, ovarian yolks and ovaries) after administration of feed contaminated with 0.27 mg kg ⁻¹ of this coccidiostat. The residues were determined using LC-MS/MS. The distribution pattern confirmed the high lipophilicity of semduramicin. Residues were found mainly in egg yolks (28.8 µg kg ⁻¹), ovarian yolks (19.5 µg kg ⁻¹) and liver (2.57 µg kg ⁻¹), while hens’ muscle was free from semduramicin (LOD = 0.1 µg kg ⁻¹). Among edible tissues, the maximum level (2 µg kg ⁻¹) was exceeded only in the liver.
ISSN:1944-0057
1944-0049
1944-0057
DOI:10.1080/19440049.2014.927593