MxA mRNA expression as a biomarker of interferon beta response in multiple sclerosis patients

Abstract Myxovirus resistance protein A (MxA) is a molecule induced after interferon-β injection. The aim of this study was to investigate whether MxA determination one year after starting interferon-β can predict treatment response in multiple sclerosis patients. MxA mRNA expression was evaluated i...

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Bibliographic Details
Published in:Journal of neuroimmunology 2016-02, Vol.291, p.73-77
Main Authors: Matas, Elisabet, Bau, Laura, Martínez-Iniesta, María, Romero-Pinel, Lucía, Mañé-Martínez, M. Alba, Cobo-Calvo, Álvaro, Martínez-Yélamos, Sergio
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism
Biomarker
Biomarkers - blood
Cohort Studies
Disability Evaluation
Female
Gene Expression Regulation - drug effects
Humans
Immunologic Factors - therapeutic use
Interferon-beta
Interferon-beta - therapeutic use
Male
Middle Aged
Multiple sclerosis
Multiple Sclerosis - drug therapy
Multiple Sclerosis - metabolism
Multiple Sclerosis - mortality
MxA
Neurology
Prospective Studies
RNA, Messenger - metabolism
Statistics, Nonparametric
Survival Analysis
Treatment response
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Summary:Abstract Myxovirus resistance protein A (MxA) is a molecule induced after interferon-β injection. The aim of this study was to investigate whether MxA determination one year after starting interferon-β can predict treatment response in multiple sclerosis patients. MxA mRNA expression was evaluated in blood samples obtained at baseline and at month 12. Clinical variables were prospectively recorded. A threshold of 5 was defined to establish MxA induction. On survival analysis, time to the next relapse and to EDSS progression were significantly longer in patients showing MxA induction, suggesting that MxA induction after one year may be useful to identify interferon-β responders.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2015.12.015