Association of type 2 diabetes mellitus with plasma organochlorine compound concentrations

• Published in: Journal of exposure science & environmental epidemiology 2016-03, Vol.26 (2), p.207-213
• Main Authors: Eden, Paul R, Meek, Edward C, Wills, Robert W, Olsen, Eric V, Crow, J Allen, Chambers, Janice E
• Format: Article
• Language: English
• Subjects: 692/699/2743/137/773; 704/172/169/895; Adult; African Americans; Aged; Analysis; Bioaccumulation; Blood plasma; Body Mass Index; Body size; Body weight; Case-Control Studies; DDE; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - etiology; Endocrine disruptors; Environmental aspects; Epidemiology; European Continental Ancestry Group; Female; Gas chromatography; Gas Chromatography-Mass Spectrometry; Health aspects; Humans; Hydrocarbons, Chlorinated - adverse effects; Hydrocarbons, Chlorinated - blood; Lipids - blood; Logistic Models; Male; Mass spectrometry; Mass spectroscopy; Medicine; Medicine & Public Health; Middle Aged; Military Personnel; Minority & ethnic groups; Mississippi; Nitrous oxide; Obesity; Obesity - complications; Ohio; Older people; Organic chlorine compounds; Organic compounds; Organochlorine compounds; original-article; Overweight; Oxychlordane; Plasma; Risk Factors; Solid phases; Type 2 diabetes; White people
• ISSN: 1559-0631; 1559-064X
• DOI: 10.1038/jes.2014.69

The increased prevalence of type 2 diabetes mellitus (T2DM) is associated with obesity, age, and sedentary lifestyle, but exposure to some organochlorine (OC) compounds has also been recently implicated. The hypothesis tested is that higher concentrations of bioaccumulative OC compounds are associated with T2DM. Plasma samples were obtained from a cross-section of adult male and female Caucasians and African Americans, either with or without T2DM from two US Air Force medical facilities. A method of extracting OC compounds from human plasma using solid phase extraction was developed, and three OC compounds [ p,p’ -DDE (DDE), trans -nonachlor, and oxychlordane] were quantified by gas chromatography/mass spectrometry. Multivariable logistic regression modeling indicated that increasing body mass index (BMI) was associated with T2DM in Caucasians but not in African Americans, and African Americans were more likely to have T2DM than Caucasians with decreasing odds ratios as BMI increased. An association between T2DM and increasing plasma DDE (adjusted for age, base, race, and BMI) was observed. Increasing DDE concentrations were associated with T2DM in older individuals and those with lower BMIs. Thus, in this study sample there was a higher risk of T2DM with increasing DDE concentrations in older people of normal weight and relatively lower risk associated with increasing DDE concentrations in those who are overweight or obese.