Natural and engineered biosynthesis of nucleoside antibiotics in Actinomycetes

Nucleoside antibiotics constitute an important family of microbial natural products bearing diverse bioactivities and unusual structural features. Their biosynthetic logics are unique with involvement of complex multi-enzymatic reactions leading to the intricate molecules from simple building blocks...

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Bibliographic Details
Published in:Journal of Industrial Microbiology & Biotechnology 2016-03, Vol.43 (2-3), p.401-417
Main Authors: Chen, Wenqing, Qi, Jianzhao, Wu, Pan, Wan, Dan, Liu, Jin, Feng, Xuan, Deng, Zixin
Format: Article
Language:English
Subjects:
Actinobacteria - enzymology
Actinobacteria - genetics
Actinobacteria - metabolism
Actinomycetales
Animals
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - chemistry
Antibiotics
bioactive properties
Biochemistry
Bioinformatics
Biological Products - chemistry
Biological Products - metabolism
Biomedical and Life Sciences
Biosynthesis
Biotechnology
drugs
Genetic Engineering
Humans
Inorganic Chemistry
Laboratories
Life Sciences
Metabolic Engineering
Microbiology
Natural products
nucleosides
Nucleosides - biosynthesis
Nucleosides - chemistry
Peptides
persuasion
Review
Studies
Synthetic Biology
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Summary:Nucleoside antibiotics constitute an important family of microbial natural products bearing diverse bioactivities and unusual structural features. Their biosynthetic logics are unique with involvement of complex multi-enzymatic reactions leading to the intricate molecules from simple building blocks. Understanding how nature builds this family of antibiotics in post-genomic era sets the stage for rational enhancement of their production, and also paves the way for targeted persuasion of the cell factories to make artificial designer nucleoside drugs and leads via synthetic biology approaches. In this review, we discuss the recent progress and perspectives on the natural and engineered biosynthesis of nucleoside antibiotics.
ISSN:1367-5435
1476-5535
DOI:10.1007/s10295-015-1636-3