Association of body mass index and the depletion of nigrostriatal dopamine in Parkinson's disease

Abstract Several antecedent studies had reported close relationship between low body weight and Parkinson's disease (PD). However, there have been few investigations about the role of body weight to nigrostriatal dopaminergic neurodegeneration. This study enrolled 398 de novo patients with PD w...

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Bibliographic Details
Published in:Neurobiology of aging 2016-02, Vol.38, p.197-204
Main Authors: Lee, Jae Jung, Oh, Jungsu S, Ham, Jee H, Lee, Dong H, Lee, Injoo, Sohn, Young H, Kim, Jae S, Lee, Phil Hyu
Format: Article
Language:English
Subjects:
Aged
Body Mass Index
Corpus Striatum - metabolism
Dopamine - deficiency
Dopamine - metabolism
Dopamine Plasma Membrane Transport Proteins - metabolism
Dopamine transporter activity
Female
Humans
Internal Medicine
Linear Models
Male
Middle Aged
Multivariate Analysis
Neurology
Parkinson Disease - etiology
Parkinson Disease - metabolism
Parkinson's disease
Substantia Nigra - metabolism
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Summary:Abstract Several antecedent studies had reported close relationship between low body weight and Parkinson's disease (PD). However, there have been few investigations about the role of body weight to nigrostriatal dopaminergic neurodegeneration. This study enrolled 398 de novo patients with PD whom underwent [18 F] N-(3-Fluoropropyl)-2β-carbon ethoxy-3β-(4-iodophenyl) nortropane positron emission tomography scan and body mass index (BMI) measurement. The relationships between BMI and dopamine transporter (DAT) activity were analyzed using linear regression analysis. A multivariate analysis adjusted for age, gender, disease duration, smoking status, coffee and tea consumption, and residence area revealed that BMI remained independently and significantly associated with DAT activity in all striatal subregions. Moreover, multiple logistic regression analyses showed that BMI was a significant predictor for the lowest quartile of DAT activity in the anterior putamen, ventral striatum, caudate nucleus, and total striatum. The present findings suggest that a low BMI might be closely associated with low density of nigrostriatal dopaminergic neurons in PD, which could support the evidence for the role of low body weight to PD-related pathologies.
ISSN:0197-4580
1558-1497
DOI:10.1016/j.neurobiolaging.2015.11.009