Assessing the connection between organophosphate pesticide poisoning and mental health: A comparison of neuropsychological symptoms from clinical observations, animal models and epidemiological studies

Psychiatry and psychology are beginning to recognize the importance of lead, mercury and heavy metals as causal partners in the development of mental disorders. Further, mental health researchers and clinicians are embracing the idea that the combined effects of genetics and environmental exposures...

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Bibliographic Details
Published in:Cortex 2016-01, Vol.74, p.405-416
Main Authors: Stallones, Lorann, Beseler, Cheryl L.
Format: Article
Language:English
Subjects:
Animals
Disease Models, Animal
Environmental Exposure - adverse effects
Epidemiology
Humans
Mental Disorders - chemically induced
Mental Health
Mood disorders
Neuropsychological Tests
Occupational Exposure - adverse effects
Organophosphate poisoning
Organophosphate Poisoning - complications
Pesticides - poisoning
Review
Toxicology
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Summary:Psychiatry and psychology are beginning to recognize the importance of lead, mercury and heavy metals as causal partners in the development of mental disorders. Further, mental health researchers and clinicians are embracing the idea that the combined effects of genetics and environmental exposures can result in perturbations in brain neurochemistry leading to psychiatric disorders. The purpose of this review is to examine the biological foundations for the epidemiological observations previously identified by reviewing the toxicology literature and relating it to epidemiological studies addressing the role of poisoning with organophosphate pesticides (OPs) in neurobehavioral and neuropsychological disorders. The goal of this review is to raise awareness in the mental health community about the possibility that affective disorders might be the result of contributions from environmental and occupational pesticide poisoning.
ISSN:0010-9452
1973-8102
DOI:10.1016/j.cortex.2015.10.002