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Association of Genetic Polymorphism in the Interleukin-8 Gene with Risk of Oral Cancer and Its Correlation with Pain
Oral cancer is a multifactorial disease process and involves complex interactions between gene to gene and gene to environmental factors. Interleukin 8 (IL-8), a pro-inflammatory cytokine, having angiogenic activity with elevated expression in tumor cells, is reported to play an essential role in or...
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Published in: | Biochemical genetics 2016-02, Vol.54 (1), p.95-106 |
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description | Oral cancer is a multifactorial disease process and involves complex interactions between gene to gene and gene to environmental factors. Interleukin 8 (IL-8), a pro-inflammatory cytokine, having angiogenic activity with elevated expression in tumor cells, is reported to play an essential role in oral cancer development. This study was conducted with the aim to investigate the role of IL-8 (-A251T) gene polymorphism in susceptibility, progression, and self-reporting pain in oral cancer. The single nucleotide polymorphisms of the IL-8 (-A251T) gene were screened in 300 patients with oral cancer and 300 healthy controls, by polymerase chain reaction-restriction fragment length polymorphism. Genotype and allele frequencies were evaluated by chi-square test and odds ratio (OR) with 95% confidence intervals (CIs) were used to evaluate the strength of associations. The results of the study demonstrated that IL-8 (-A251T) gene polymorphism was significantly associated with susceptibility of oral cancer, whereas its correlation with clinico-pathological status or pain due to oral cancer could not be established. The AT heterozygous (OR 5.31; CI 3.38–8.34; p 0.0001) and AA homozygous (OR 2.89; CI 1.76–4.75; p 0.0001) had a greater risk for oral cancer compared to TT homozygous. Furthermore, significantly increased values of A allele frequencies compared to T allele were observed in all patients (OR 1.56; CI 1.24–1.96; p 0.0002). Tobacco chewing and smoking were also found to influence the development of oral cancer and increased the incidence of pain in oral cancer patients. The findings of this study suggest that the IL-8 (-A251T) gene polymorphism may be associated with increased risk of oral cancer. |
doi_str_mv | 10.1007/s10528-015-9704-y |
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Interleukin 8 (IL-8), a pro-inflammatory cytokine, having angiogenic activity with elevated expression in tumor cells, is reported to play an essential role in oral cancer development. This study was conducted with the aim to investigate the role of IL-8 (-A251T) gene polymorphism in susceptibility, progression, and self-reporting pain in oral cancer. The single nucleotide polymorphisms of the IL-8 (-A251T) gene were screened in 300 patients with oral cancer and 300 healthy controls, by polymerase chain reaction-restriction fragment length polymorphism. Genotype and allele frequencies were evaluated by chi-square test and odds ratio (OR) with 95% confidence intervals (CIs) were used to evaluate the strength of associations. The results of the study demonstrated that IL-8 (-A251T) gene polymorphism was significantly associated with susceptibility of oral cancer, whereas its correlation with clinico-pathological status or pain due to oral cancer could not be established. The AT heterozygous (OR 5.31; CI 3.38–8.34; p 0.0001) and AA homozygous (OR 2.89; CI 1.76–4.75; p 0.0001) had a greater risk for oral cancer compared to TT homozygous. Furthermore, significantly increased values of A allele frequencies compared to T allele were observed in all patients (OR 1.56; CI 1.24–1.96; p 0.0002). Tobacco chewing and smoking were also found to influence the development of oral cancer and increased the incidence of pain in oral cancer patients. The findings of this study suggest that the IL-8 (-A251T) gene polymorphism may be associated with increased risk of oral cancer.</description><identifier>ISSN: 0006-2928</identifier><identifier>EISSN: 1573-4927</identifier><identifier>DOI: 10.1007/s10528-015-9704-y</identifier><identifier>PMID: 26660080</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Case-Control Studies ; Environmental factors ; Female ; Human Genetics ; Humans ; Interleukin-8 - genetics ; Male ; Medical Microbiology ; Middle Aged ; Mouth Neoplasms - complications ; Mouth Neoplasms - genetics ; Original Article ; Pain ; Pain - etiology ; Polymorphism, Single Nucleotide ; Zoology</subject><ispartof>Biochemical genetics, 2016-02, Vol.54 (1), p.95-106</ispartof><rights>Springer Science+Business Media New York 2015</rights><rights>Springer Science+Business Media New York 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-379b08da064dee43b82310d553545b612a68e8c7970f3b156769fd59c94fcfaa3</citedby><cites>FETCH-LOGICAL-c499t-379b08da064dee43b82310d553545b612a68e8c7970f3b156769fd59c94fcfaa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26660080$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singh, Prithvi Kumar</creatorcontrib><creatorcontrib>Chandra, Girish</creatorcontrib><creatorcontrib>Bogra, Jaishri</creatorcontrib><creatorcontrib>Gupta, Rajni</creatorcontrib><creatorcontrib>Kumar, Vijay</creatorcontrib><creatorcontrib>Hussain, Syed Rizwan</creatorcontrib><creatorcontrib>Jain, Amita</creatorcontrib><creatorcontrib>Mahdi, Abbas Ali</creatorcontrib><creatorcontrib>Ahmad, Mohammad Kaleem</creatorcontrib><title>Association of Genetic Polymorphism in the Interleukin-8 Gene with Risk of Oral Cancer and Its Correlation with Pain</title><title>Biochemical genetics</title><addtitle>Biochem Genet</addtitle><addtitle>Biochem Genet</addtitle><description>Oral cancer is a multifactorial disease process and involves complex interactions between gene to gene and gene to environmental factors. Interleukin 8 (IL-8), a pro-inflammatory cytokine, having angiogenic activity with elevated expression in tumor cells, is reported to play an essential role in oral cancer development. This study was conducted with the aim to investigate the role of IL-8 (-A251T) gene polymorphism in susceptibility, progression, and self-reporting pain in oral cancer. The single nucleotide polymorphisms of the IL-8 (-A251T) gene were screened in 300 patients with oral cancer and 300 healthy controls, by polymerase chain reaction-restriction fragment length polymorphism. Genotype and allele frequencies were evaluated by chi-square test and odds ratio (OR) with 95% confidence intervals (CIs) were used to evaluate the strength of associations. The results of the study demonstrated that IL-8 (-A251T) gene polymorphism was significantly associated with susceptibility of oral cancer, whereas its correlation with clinico-pathological status or pain due to oral cancer could not be established. The AT heterozygous (OR 5.31; CI 3.38–8.34; p 0.0001) and AA homozygous (OR 2.89; CI 1.76–4.75; p 0.0001) had a greater risk for oral cancer compared to TT homozygous. Furthermore, significantly increased values of A allele frequencies compared to T allele were observed in all patients (OR 1.56; CI 1.24–1.96; p 0.0002). Tobacco chewing and smoking were also found to influence the development of oral cancer and increased the incidence of pain in oral cancer patients. The findings of this study suggest that the IL-8 (-A251T) gene polymorphism may be associated with increased risk of oral cancer.</description><subject>Adult</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Case-Control Studies</subject><subject>Environmental factors</subject><subject>Female</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Interleukin-8 - genetics</subject><subject>Male</subject><subject>Medical Microbiology</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - complications</subject><subject>Mouth Neoplasms - genetics</subject><subject>Original Article</subject><subject>Pain</subject><subject>Pain - etiology</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Zoology</subject><issn>0006-2928</issn><issn>1573-4927</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNkc1u1DAUhS0EokPhAdiAJTZs0l47_l1WIygjVWpV6NpyEqfjNrEHO1E1b4-nKQixqFhZV_7OuffoIPSewAkBkKeZAKeqAsIrLYFV-xdoRbisK6apfIlWACAqqqk6Qm9yviujBsZeoyMqhABQsELTWc6x9XbyMeDY43MX3ORbfBWH_RjTbuvziH3A09bhTZhcGtx870OlHkn84Kctvvb5_qC9THbAaxtal7ANHd5MGa9jSm5Y7B_hK-vDW_Sqt0N2757eY3Tz9cuP9bfq4vJ8sz67qFqm9VTVUjegOguCdc6xulG0JtBxXnPGG0GoFcqpVpbsfd0QLqTQfcd1q1nf9tbWx-jz4rtL8efs8mRGn1s3DDa4OGdDpFBcUSLY_6CgKRBGC_rpH_QuzimUIIXiSkklJS8UWag2xZyT680u-dGmvSFgDu2ZpT1T2jOH9sy-aD48Oc_N6Lo_it91FYAuQC5f4dalv1Y_4_pxEfU2GnubfDY330uUYkmYYOXWX4h8rRA</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Singh, Prithvi Kumar</creator><creator>Chandra, Girish</creator><creator>Bogra, Jaishri</creator><creator>Gupta, Rajni</creator><creator>Kumar, Vijay</creator><creator>Hussain, Syed Rizwan</creator><creator>Jain, Amita</creator><creator>Mahdi, Abbas Ali</creator><creator>Ahmad, Mohammad Kaleem</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7SS</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20160201</creationdate><title>Association of Genetic Polymorphism in the Interleukin-8 Gene with Risk of Oral Cancer and Its Correlation with Pain</title><author>Singh, Prithvi Kumar ; Chandra, Girish ; Bogra, Jaishri ; Gupta, Rajni ; Kumar, Vijay ; Hussain, Syed Rizwan ; Jain, Amita ; Mahdi, Abbas Ali ; Ahmad, Mohammad Kaleem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-379b08da064dee43b82310d553545b612a68e8c7970f3b156769fd59c94fcfaa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Case-Control Studies</topic><topic>Environmental factors</topic><topic>Female</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Interleukin-8 - 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Academic</collection><jtitle>Biochemical genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singh, Prithvi Kumar</au><au>Chandra, Girish</au><au>Bogra, Jaishri</au><au>Gupta, Rajni</au><au>Kumar, Vijay</au><au>Hussain, Syed Rizwan</au><au>Jain, Amita</au><au>Mahdi, Abbas Ali</au><au>Ahmad, Mohammad Kaleem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Genetic Polymorphism in the Interleukin-8 Gene with Risk of Oral Cancer and Its Correlation with Pain</atitle><jtitle>Biochemical genetics</jtitle><stitle>Biochem Genet</stitle><addtitle>Biochem Genet</addtitle><date>2016-02-01</date><risdate>2016</risdate><volume>54</volume><issue>1</issue><spage>95</spage><epage>106</epage><pages>95-106</pages><issn>0006-2928</issn><eissn>1573-4927</eissn><abstract>Oral cancer is a multifactorial disease process and involves complex interactions between gene to gene and gene to environmental factors. Interleukin 8 (IL-8), a pro-inflammatory cytokine, having angiogenic activity with elevated expression in tumor cells, is reported to play an essential role in oral cancer development. This study was conducted with the aim to investigate the role of IL-8 (-A251T) gene polymorphism in susceptibility, progression, and self-reporting pain in oral cancer. The single nucleotide polymorphisms of the IL-8 (-A251T) gene were screened in 300 patients with oral cancer and 300 healthy controls, by polymerase chain reaction-restriction fragment length polymorphism. Genotype and allele frequencies were evaluated by chi-square test and odds ratio (OR) with 95% confidence intervals (CIs) were used to evaluate the strength of associations. The results of the study demonstrated that IL-8 (-A251T) gene polymorphism was significantly associated with susceptibility of oral cancer, whereas its correlation with clinico-pathological status or pain due to oral cancer could not be established. The AT heterozygous (OR 5.31; CI 3.38–8.34; p 0.0001) and AA homozygous (OR 2.89; CI 1.76–4.75; p 0.0001) had a greater risk for oral cancer compared to TT homozygous. Furthermore, significantly increased values of A allele frequencies compared to T allele were observed in all patients (OR 1.56; CI 1.24–1.96; p 0.0002). Tobacco chewing and smoking were also found to influence the development of oral cancer and increased the incidence of pain in oral cancer patients. The findings of this study suggest that the IL-8 (-A251T) gene polymorphism may be associated with increased risk of oral cancer.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>26660080</pmid><doi>10.1007/s10528-015-9704-y</doi><tpages>12</tpages></addata></record> |
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subjects | Adult Biochemistry Biomedical and Life Sciences Biomedicine Case-Control Studies Environmental factors Female Human Genetics Humans Interleukin-8 - genetics Male Medical Microbiology Middle Aged Mouth Neoplasms - complications Mouth Neoplasms - genetics Original Article Pain Pain - etiology Polymorphism, Single Nucleotide Zoology |
title | Association of Genetic Polymorphism in the Interleukin-8 Gene with Risk of Oral Cancer and Its Correlation with Pain |
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