Tamoxifen promotes differentiation of oligodendrocyte progenitors in vitro

Highlights • Tamoxifen (TMX), 4-hydroxy-TMX (4-OHTMX) and endoxifen promote oligodendrogenesis in vitro. • TMXs promote estrogen receptor (ER)-dependent oligodendrogenesis, not reported before. • In contrast to TMX and 4-OHTMX, endoxifen induces ER-independent astrogliogenesis. • Differentiating eff...

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Bibliographic Details
Published in:Neuroscience 2016-04, Vol.319, p.146-154
Main Authors: Barratt, H.E, Budnick, H.C, Parra, R, Lolley, R.J, Perry, C.N, Nesic, O
Format: Article
Language:English
Subjects:
4-hydroxy-tamoxifen
Animals
astrocytes
Blotting, Western
Cell Differentiation - drug effects
endoxifen
estrogen receptors
Fluorescent Antibody Technique
Neural Stem Cells - cytology
Neural Stem Cells - drug effects
Neurology
oligodendrocyte progenitors
Oligodendroglia - cytology
Oligodendroglia - drug effects
Prodrugs - pharmacology
Rats
tamoxifen
Tamoxifen - analogs & derivatives
Tamoxifen - pharmacology
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Summary:Highlights • Tamoxifen (TMX), 4-hydroxy-TMX (4-OHTMX) and endoxifen promote oligodendrogenesis in vitro. • TMXs promote estrogen receptor (ER)-dependent oligodendrogenesis, not reported before. • In contrast to TMX and 4-OHTMX, endoxifen induces ER-independent astrogliogenesis. • Differentiating effects of TMX were achieved with clinically safe doses. • TMX is a promising candidate for the treatment of demyelinating diseases.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.01.026