Significant hepatic expression of IL-2 and IL-8 in biliary atresia compared with other neonatal cholestatic disorders

•IL-2 and IL-8 hepatic expression is significantly higher in biliary atresia.•Platelet count is significantly higher in biliary atresia.•IL-2 and IL-8 neutralizing antibodies may be a potential therapy in biliary atresia. Although the exact etiology of biliary atresia (BA) is still elusive, inflamma...

Full description

Saved in:
Bibliographic Details
Published in:Cytokine (Philadelphia, Pa.) Pa.), 2016-03, Vol.79, p.59-65
Main Authors: Arafa, Reda Sanad, Abdel Haie, Omima M., El-Azab, Dina Shehata, Abdel-Rahman, Amira Mohamed, Sira, Mostafa M.
Format: Article
Language:English
Subjects:
Biliary atresia
Biliary Atresia - pathology
Cholestasis - pathology
Etiopathogenesis
Female
Ferritins - blood
Humans
Immunostaining
Infant
Infant, Newborn
Inflammation - pathology
Interleukin 2
Interleukin 8
Interleukin-2 - biosynthesis
Interleukin-8 - biosynthesis
Liver - pathology
Liver Diseases - pathology
Male
Neonatal cholestasis
Retrospective Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•IL-2 and IL-8 hepatic expression is significantly higher in biliary atresia.•Platelet count is significantly higher in biliary atresia.•IL-2 and IL-8 neutralizing antibodies may be a potential therapy in biliary atresia. Although the exact etiology of biliary atresia (BA) is still elusive, inflammation plays a key role. Release of proinflammatory cytokines from activated immune cells perpetuates the injury and causes biliary destruction. We aimed to study interleukin (IL)-2 and IL-8 expression in liver tissue of BA patients compared with other neonatal cholestatic disorders. The study included 59 infants with neonatal cholestasis in two groups; BA group (n=31) and non-BA group (n=28) with cholestatic disorders other than BA as controls. Demographic, clinical, laboratory, and histopathological parameters were collected. IL-2 and IL-8 immunostaining was performed. Immunostaining in portal cellular infiltrate was scored as positive or negative and expressed as the mean cell count in three portal tracts. The mean value of IL-2 and IL-8 positive inflammatory cells was significantly higher in BA than in non-BA group (P-values of 0.004 and 0.002 respectively). IL-2 correlated significantly with IL-8 immunostaining in both BA and non-BA group (P
ISSN:1043-4666
1096-0023
DOI:10.1016/j.cyto.2015.12.023