Adult adiposity susceptibility loci, early growth and general and abdominal fatness in childhood: the Generation R Study

• Published in: International Journal of Obesity 2015-06, Vol.39 (6), p.1001-1009
• Main Authors: Vogelezang, S, Monnereau, C, Gaillard, R, Renders, C M, Hofman, A, Jaddoe, V W V, Felix, J F
• Format: Article
• Language: English
• Subjects: 45; 45/43; 631/208/135; 692/499; Abdomen; Abdominal Fat; Adipose tissue; Adipose tissues; Adiposity - genetics; Adolescent; Adult; Adults; Age; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Body fat; Body Fat Distribution; Body height; Body Mass Index; Body size; Cell Adhesion Molecules, Neuronal - genetics; Child; Child Development; Child, Preschool; Childhood; Children; Children & youth; Cohort analysis; Confidence intervals; Disease Susceptibility - epidemiology; Epidemiology; Female; Gene loci; Genetic aspects; Genetic diversity; Genetic markers; Genetic variance; Genome-Wide Association Study; Genomes; GPI-Linked Proteins - genetics; Growth patterns; Health aspects; Health Promotion and Disease Prevention; Health risk assessment; Hip; Humans; Infant; Infant, Newborn; Internal Medicine; Male; Markers; Medicine; Medicine & Public Health; Membrane Proteins - genetics; Metabolic Diseases; Obesity; Obesity in children; original-article; Pediatric research; Physiological aspects; Polymorphism, Single Nucleotide - genetics; Population studies; Prospective Studies; Proteins - genetics; Public Health; Quantitative trait loci; Risk; Risk Factors; Single nucleotide polymorphisms; Velocity; Waist-Hip Ratio; Weight Gain - genetics
• ISSN: 0307-0565; 1476-5497
• DOI: 10.1038/ijo.2015.12

Background: Genome-wide association studies in adults have identified genetic loci associated with adiposity measures. Little is known about the effects of these loci on growth and body fat distribution from early childhood onwards. Methods: In a population-based prospective cohort study among 4144 children, we examined the associations of weighted risk scores combining 29 known genetic markers of adult body mass index (BMI) and 14 known genetic markers of adult waist-hip ratio (WHR) with peak weight velocity, peak height velocity, age at adiposity peak and BMI at adiposity peak in early infancy and additionally with BMI, total fat mass, android/gynoid fat ratio and preperitoneal fat area at the median age of 6.0 years (95% range 5.7, 7.8). Results: A higher adult BMI genetic risk score was associated with a higher age at adiposity peak in infancy and a higher BMI, total fat mass, android/gynoid fat ratio and preperitoneal fat area in childhood ( P =0.05, 1.5 × 10 −24 , 3.6 × 10 −18 , 4.0 × 10 −11 and 1.3 × 10 −5 , respectively), with the strongest association for childhood BMI with a 0.04 higher s.d. score BMI (95% confidence interval 0.03, 0.05) per additional risk allele. A higher adult WHR genetic risk score was not associated with infant growth measures or childhood BMI and total fat mass, but was associated with childhood android/gynoid fat ratio and preperitoneal fat area ( P