Alpha-Lipoic Acid Attenuates Oxidative Damage in Organs After Sepsis

Sepsis progression is linked with the imbalance between reactive oxygen species and antioxidant enzymes. Thus, the aim of this study was to evaluate the effect of alpha-lipoic acid (ALA), a powerful antioxidant, in organs of rats submitted to sepsis. Male Wistar rats were subjected to sepsis by ceca...

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Bibliographic Details
Published in:Inflammation 2016-02, Vol.39 (1), p.357-365
Main Authors: Petronilho, Fabricia, Florentino, Drielly, Danielski, Lucinéia Gainski, Vieira, Luiz Carlos, Martins, Maryane Modolon, Vieira, Andriele, Bonfante, Sandra, Goldim, Mariana Pereira, Vuolo, Francieli
Format: Article
Language:English
Subjects:
Animals
Antioxidants - therapeutic use
Biomedical and Life Sciences
Biomedicine
Catalase - metabolism
Cecum - surgery
Immunology
Inflammation - drug therapy
Internal Medicine
Kidney - enzymology
Kidney - pathology
Lipid Peroxidation - drug effects
Liver - enzymology
Liver - pathology
Lung - enzymology
Lung - pathology
Male
Myocardium - enzymology
Myocardium - pathology
Neutrophil Infiltration - drug effects
Neutrophil Infiltration - immunology
Original Article
Oxidative Stress - drug effects
Pathology
Peroxidase - metabolism
Pharmacology/Toxicology
Protein Carbonylation - drug effects
Rats
Rats, Wistar
Reactive Oxygen Species - metabolism
Rheumatology
Sepsis - immunology
Sepsis - pathology
Superoxide Dismutase - metabolism
Thioctic Acid - therapeutic use
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Summary:Sepsis progression is linked with the imbalance between reactive oxygen species and antioxidant enzymes. Thus, the aim of this study was to evaluate the effect of alpha-lipoic acid (ALA), a powerful antioxidant, in organs of rats submitted to sepsis. Male Wistar rats were subjected to sepsis by cecal ligation puncture (CLP) and treated with ALA or vehicle. After CLP (12 and 24 h), the myeloperoxidase (MPO) activity, protein and lipid oxidative damage, and antioxidant enzymes in the liver, kidney, heart, and lung were evaluated. ALA was effective in reducing MPO activity, lipid peroxidation in the liver, and protein carbonylation only in the kidney in 12 h after CLP. In 12 h, SOD activity increased in the kidney and CAT activity in the liver and kidney with ALA treatment. Thus, ALA was able to reduce the inflammation and oxidative stress in the liver and kidney after sepsis in rats.
ISSN:0360-3997
1573-2576
DOI:10.1007/s10753-015-0256-4