Multiplex Brain Proteomic Analysis Revealed the Molecular Therapeutic Effects of Buyang Huanwu Decoction on Cerebral Ischemic Stroke Mice: e0140823

Stroke is the second-leading cause of death worldwide, and tissue plasminogen activator (TPA) is the only drug used for a limited group of stroke patients in the acute phase. Buyang Huanwu Decoction (BHD), a traditional Chinese medicine prescription, has long been used for improving neurological fun...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2015-10, Vol.10 (10)
Main Authors: Chen, Hong-Jhang, Shen, Yuh-Chiang, Shiao, Young-Ji, Liou, Kuo-Tong, Hsu, Wei-Hsiang, Hsieh, Pei-Hsuan, Lee, Chi-Ying, Chen, Yet-Ran, Lin, Yun-Lian
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Stroke is the second-leading cause of death worldwide, and tissue plasminogen activator (TPA) is the only drug used for a limited group of stroke patients in the acute phase. Buyang Huanwu Decoction (BHD), a traditional Chinese medicine prescription, has long been used for improving neurological functional recovery in stroke. In this study, we characterized the therapeutic effect of TPA and BHD in a cerebral ischemia/reperfusion (CIR) injury mouse model using multiplex proteomics approach. After the iTRAQ-based proteomics analysis, 1310 proteins were identified from the mouse brain with
ISSN:1932-6203
DOI:10.1371/journal.pone.0140823