Toxicity assessment of Clostridium difficile toxins in rodent models and protection of vaccination

Highlights • Clostridium difficile binary toxins (CDTa and CDTb) are lethal in mice and hamsters. • Mice can be used as animal model to evaluate toxicity for C. difficile toxins. • Immunized mice are protected from lethality upon direct toxins injection challenge.

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Bibliographic Details
Published in:Vaccine 2016-03, Vol.34 (10), p.1319-1323
Main Authors: Wang, Su, Rustandi, Richard R, Lancaster, Catherine, Hong, Laura G, Thiriot, David S, Xie, Jinfu, Secore, Susan, Kristopeit, Adam, Wang, Sheng-Ching, Heinrichs, Jon H
Format: Article
Language:English
Subjects:
ADP Ribose Transferases - toxicity
Allergy and Immunology
Animals
Antigens
Bacterial Proteins - toxicity
Bacterial Toxins - toxicity
Binary toxin
Clostridium difficile
Clostridium difficile - pathogenicity
Clostridium difficile toxins
Cricetinae
E coli
Enterotoxins - toxicity
Experiments
Female
Immunization
LD50
Lethal Dose 50
Male
Mice
Mice model
Mice, Inbred C57BL
Monitoring methods
Pathogenesis
Pathogens
Protection
Toxicity
Toxins
Toxoids - toxicity
Vaccine
Vaccines
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Description
Summary:Highlights • Clostridium difficile binary toxins (CDTa and CDTb) are lethal in mice and hamsters. • Mice can be used as animal model to evaluate toxicity for C. difficile toxins. • Immunized mice are protected from lethality upon direct toxins injection challenge.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2015.11.026