Green approaches to late-stage fluorination: radiosyntheses of super(18)F-labelled radiopharmaceuticals in ethanol and water

Green strategies for late-stage fluorination with super(18)F, in which ethanol and water are the only solvents used throughout the entire radiolabeling process (azeotropic drying, nucleophilic fluorination, purification and formulation), have been developed and applied to the radiosyntheses of a ran...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2015-09, Vol.51 (79), p.14805-14808
Main Authors: Stewart, Megan N, Hockley, Brian G, Scott, Peter JH
Format: Article
Language:English
Subjects:
Drying
Ethanol
Ethyl alcohol
Fluorination
Purification
Solvents
Strategy
Tomography
Online Access:Get full text
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Summary:Green strategies for late-stage fluorination with super(18)F, in which ethanol and water are the only solvents used throughout the entire radiolabeling process (azeotropic drying, nucleophilic fluorination, purification and formulation), have been developed and applied to the radiosyntheses of a range of radiopharmaceuticals commonly employed in clinical PET imaging.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc05919d