Reduced taste function and taste papillae density in children with chronic kidney disease

Background Taste loss may contribute to the loss of appetite in children with chronic kidney disease (CKD) and other serious medical conditions that result in malnutrition. Traditional methods for measurement of taste loss commonly use aqueous tastant solutions that can induce nausea, vomiting, or e...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2015-11, Vol.30 (11), p.2003-2010
Main Authors: Correa, Maryam, Laing, David G., Hutchinson, Ian, Jinks, Anthony L., Armstrong, Jessica E., Kainer, Gad
Format: Article
Language:English
Subjects:
Adolescent
Child
Child, Preschool
Chronic kidney failure
Complications and side effects
Digital cameras
Female
Food
Humans
Kidney diseases
Male
Medicine
Medicine & Public Health
Methods
Nephrology
Original Article
Pediatrics
Photography
Physiological aspects
Renal Insufficiency, Chronic - complications
Risk factors
Stains & staining
Taste buds
Taste Buds - pathology
Taste disorders
Taste Disorders - etiology
Taste Disorders - pathology
Tongue
Urology
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Summary:Background Taste loss may contribute to the loss of appetite in children with chronic kidney disease (CKD) and other serious medical conditions that result in malnutrition. Traditional methods for measurement of taste loss commonly use aqueous tastant solutions that can induce nausea, vomiting, or even pain in the mouth. An alternative is to measure fungiform papillae density on the anterior tongue since this correlates with taste sensitivity. Here we aimed to develop a non-invasive method for assessing papillae density on the anterior tongue and to use the method to determine if CKD patients [estimated glomerular filtrate (eGFR  89 ml/min/1.73 m 2 ). Methods Thirty-five healthy adults participated in the development of a method, which was assessed by 24 children, 12 of whom were CKD patients and 12 were clinical controls. Results Similar papillae densities were found using invasive and non-invasive methods (F (1,34)  = 0.647, p  = 0.427). The CKD group had a significantly lower papillae density (X 2  = 7.17, p  = 0.007) and poorer taste sensitivity than the CC group ( p  = 0.0272), and the density correlated significantly with eGFR ( r  = 0.56, p  
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-015-3131-5