The protective effect of blueberry anthocyanins against perfluorooctanoic acid-induced disturbance in planarian (Dugesia japonica)

The influence of blueberry anthocyanins on perfluorooctanoic acid (PFOA)-induced stress response in planarian mitochondria was investigated. PFOA at 15mg/L and anthocyanins at 10 or 20mg/L were individually and simultaneously administered to planarians for up to 10d. The results showed PFOA treatmen...

Full description

Saved in:
Bibliographic Details
Published in:Ecotoxicology and environmental safety 2016-05, Vol.127, p.170-174
Main Authors: Yuan, Zuoqing, Zhang, Jianyong, Tu, Changchao, Wang, Zhijing, Xin, Wenpeng
Format: Article
Language:English
Subjects:
Animals
Anthocyanins
Anthocyanins - pharmacology
Antioxidants - metabolism
Blueberry Plants - chemistry
Caprylates - antagonists & inhibitors
Caprylates - toxicity
Dugesia japonica
Enzyme activities
Fluorocarbons - antagonists & inhibitors
Fluorocarbons - toxicity
Mitochondria
Mitochondria - drug effects
Mitochondria - enzymology
Perfluorooctanoic acid (PFOA)
Planarians - drug effects
Plant Extracts - pharmacology
Total antioxidant capacity
Vaccinium
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The influence of blueberry anthocyanins on perfluorooctanoic acid (PFOA)-induced stress response in planarian mitochondria was investigated. PFOA at 15mg/L and anthocyanins at 10 or 20mg/L were individually and simultaneously administered to planarians for up to 10d. The results showed PFOA treatment induced an increase in mitochondrial permeability transition pore opening and a decrease antioxidant capacity and enzyme activities. In anthocyanin treated animals, the activity of succinate dehydrogenase, cytochrome oxidase and monoamine oxidase increased, but mitochondrial permeability transition pore opening decreased and total antioxidant capacity increased. An improvement in above-mentioned physiological and biochemical parameters was found in the combined PFOA and anthocyanin treated animals, in a dose-dependent manner. Anthocyanins attenuated the PFOA induced toxicity; antioxidant capacity and enzyme activities are involved in the protective mechanism of anthocyanins. •The exposure of planarians to PFOA and anthocyanins led to effects at cellular level.•The toxicity of PFOA on mitochondrial function was assessed.•Anthocyanin exposure provided protective effect against PFOA toxicity.
ISSN:0147-6513
1090-2414
DOI:10.1016/j.ecoenv.2016.01.019