Vitamin E deficiency has different effects on brain and liver phospholipid hydroperoxide glutathione peroxidase activities in the rat

The effect of vitamin E deficiency on glutathione peroxidase activity (GPX) and on the activity of a selenoenzyme (phospholipid hydroperoxide glutathione peroxidase (PHGPX) was measured in rat brain and liver. In brain, the activity of both enzymes was in the same range in homogenate and in microsom...

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Bibliographic Details
Published in:Neuroscience letters 2000-06, Vol.286 (2), p.87-90
Main Authors: Bourre, Jean-Marie, Dumont, Odile, Clément, Michel, Dinh, Lan, Droy-Lefaix, Marie-Thérese, Christen, Yves
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain
Brain - cytology
Brain - drug effects
Brain - enzymology
Cell Death - drug effects
Cell Death - physiology
Desaturase
Female
Free Radicals - adverse effects
Glutathione peroxidase
Glutathione Peroxidase - analysis
Glutathione Peroxidase - drug effects
Glutathione Peroxidase - metabolism
Lipid Peroxidation - drug effects
Liver
Liver - cytology
Liver - drug effects
Liver - enzymology
Medical sciences
Metabolic diseases
Neuroprotective Agents - pharmacology
Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)
Phospholipid hydroperoxide glutathione peroxidase
Polyunsaturated fatty acids
Rats
Rats, Sprague-Dawley
Vitamin E
Vitamin E - pharmacology
Vitamin E Deficiency - metabolism
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Summary:The effect of vitamin E deficiency on glutathione peroxidase activity (GPX) and on the activity of a selenoenzyme (phospholipid hydroperoxide glutathione peroxidase (PHGPX) was measured in rat brain and liver. In brain, the activity of both enzymes was in the same range in homogenate and in microsomes. In contrast, in liver homogenate, PHGPX activity was approximately 20 times lower than that of GPX. Very interestingly, PHGPX activity was significantly decreased in brain microsomes by vitamin E deficiency, but slightly significantly increased in liver microsomes. In contrast, GPX activity was not affected in brain by vitamin E deficiency, but was significantly lower in liver homogenate and microsomes. Thus, PHGPX activity is partially controlled by vitamin E in membranes, and PHGPX is probably an enzyme different from GPX.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(00)01095-8