Inhibitory Activity against Tobacco Mosaic Virus (TMV) Replication of Pinoresinol and Syringaresinol Lignans and Their Glycosides from the Root of Rhus javanica var. roxburghiana

• Published in: Journal of agricultural and food chemistry 2007-08, Vol.55 (16), p.6460-6465
• Main Authors: Ouyang, Ming-An, Wein, Yung-Shung, Zhang, Zhen-Kun, Kuo, Yueh-Hsiung
• Format: Article
• Language: English
• Subjects: antiviral properties; Biological and medical sciences; chemical structure; Food industries; Fundamental and applied biological sciences. Psychology; Furans - pharmacology; glycosides; Glycosides - pharmacology; lignans; Lignans - pharmacology; pinoresinol; Plant Roots - chemistry; Rhus; Rhus - chemistry; Rhus javanica var. roxburghiana; roots; syringaresinol; Tobacco mosaic virus; Tobacco Mosaic Virus - drug effects; virus replication; Virus Replication - drug effects
• ISSN: 0021-8561; 1520-5118
• DOI: 10.1021/jf0709808

Four new diepoxylignan glycosides, pinoresinol-4‘-O-[6‘ ‘-O-(E)-feruloyl]-β-d-glucopyranoside (1), pinoresinol-4‘-O-[4‘ ‘,6‘ ‘-O-(E)-diferuloyl]-β-d-glucopyranoside (2), pinoresinol-4‘-O-[3‘ ‘,6‘ ‘-O-(E)-diferuloyl]-β-d-glucopyranoside (3), and syringaresinol- 4‘-O-[4‘ ‘,6‘ ‘-O-(E)-diferuloyl]-β-d-glucopyranoside (4), together with three known compounds, pinoresinol (5), syringaresinol (6), and pinoresinol-4‘-O-β-d-glucopyranoside (7), were isolated from the n-butanol extract of Rhus javanica var. roxburghiana, and their structures were established using various spectroscopic techniques. Three glycosides (2−4) of the lignans showed moderate inhibition of multiplication of the tobacco mosaic virus. Keywords: Anacardiaceae; Rhus javanica; roots; lignan; glycoside; TMV