Left Ventricular Mass Indexing in Infants, Children, and Adolescents: A Simplified Approach for the Identification of Left Ventricular Hypertrophy in Clinical Practice

Objective To determine a simplified method to identify presence of left ventricular hypertrophy (LVH) in pediatric populations because the relationship between heart growth and body growth in children has made indexing difficult for younger ages. Study design Healthy children (n = 400; 52% boys, 0-1...

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Bibliographic Details
Published in:The Journal of pediatrics 2016-03, Vol.170, p.193-198
Main Authors: Chinali, Marcello, MD, Emma, Francesco, MD, Esposito, Claudia, MD, Rinelli, Gabriele, MD, Franceschini, Alessio, MD, Doyon, Anke, MD, Raimondi, Francesca, MD, Pongiglione, Giacomo, MD, Schaefer, Franz, MD, Matteucci, Maria Chiara, MD
Format: Article
Language:English
Subjects:
Adolescent
Body Height
Child
Child, Preschool
Echocardiography
Female
Germany
Heart Ventricles - diagnostic imaging
Humans
Hypertrophy, Left Ventricular - diagnostic imaging
Infant
Infant, Newborn
Italy
Male
Models, Cardiovascular
Pediatrics
Reference Values
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Summary:Objective To determine a simplified method to identify presence of left ventricular hypertrophy (LVH) in pediatric populations because the relationship between heart growth and body growth in children has made indexing difficult for younger ages. Study design Healthy children (n = 400; 52% boys, 0-18 years of age) from 2 different European hospitals were studied to derive a simplified formula. Left ventricular mass (LVM) was calculated according to the Devereux formula. The derived approach to index LVM was tested on a validation cohort of 130 healthy children from a different hospital center. Results There was a strong nonlinear correlation between height and LVM. LVM was best related to height to a power of 2.16 with a correction factor of 0.09. Analysis of residuals for LVM/[(height2.16 ) + 0.09] showed an homoscedastic distribution in both sexes throughout the entire height range. A partition value of 45 g/m2.16 was defined as the upper normal limit for LVM index. As opposed to formula suggested by current guidelines (ie, LVM/height2.7 ) when applying the proposed approach in the validation cohort of 130 healthy participants, no false positives for LVH were found (0% vs 8%; P  
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2015.10.085