Early Mortality and Long-term Survival after Repair of Post-infarction Ventricular Septal Rupture: An Institutional Report of Experience

• Published in: Heart, lung & circulation lung & circulation, 2016-04, Vol.25 (4), p.384-391
• Main Authors: Yalçınkaya, Adnan, MD, Lafçı, Gökhan, MD, Diken, Adem İlkay, MD, Aksoy, Eray, MD, Çiçek, Ömer Faruk, MD, Lafçı, Ayşe, MD, Korkmaz, Kemal, MD, Çağlı, Kerim, MD, PhD
• Format: Article
• Language: English
• Subjects: Aged; Cardiovascular; Disease-Free Survival; Female; Hospital Mortality; Humans; Male; Middle Aged; Myocardial infarction; Myocardial Infarction - complications; Myocardial Infarction - mortality; Myocardial Infarction - physiopathology; Myocardial Infarction - surgery; Survival; Survival Rate; Time Factors; Ventricular septal rupture; Ventricular Septal Rupture - etiology; Ventricular Septal Rupture - mortality; Ventricular Septal Rupture - physiopathology
• ISSN: 1443-9506; 1444-2892
• DOI: 10.1016/j.hlc.2015.08.016

Background To determine predictors of mortality after surgical management of post-infarction ventricular septal rupture repair. Methods A total of 63 patients (73.2%, mean age 67.22±7.71 years, male:female ratio; 35:28) underwent open heart surgery for post-infarction ventricular septal rupture repair. Patient demographics, operative data and postoperative parameters were analysed to reveal predictors of early mortality and long-term survival. Results In-hospital mortality was 54.0% (34/63). Time from myocardial infarction to operation ≤ 14 days (OR: 4.10, 95% CI 1.16-14.46, p=0.02), systolic pulmonary artery pressure > 45 mmHg (OR: 4.14, 95% CI 1.110-15.496, p=0.03) and age (years) (OR: 1.09, 95% CI 1.002-1.194, p=0.04) were found to be independent predictors of in-hospital mortality. In multivariate Cox regression analysis, presence of pulmonary oedema on admission (HR: 4.95, 95% CI 1.58-15.54, p=0.006), age (years) (HR: 1.09, 95% CI 1.009-1.180, p= 0.02) and cross-clamp time