Vasculitic Ulcers

Vasculitic ulcers are an emerging problem in wound care that needs to be well defined and adequately approached by caregivers. Cutaneous vasculitis includes several inflammatory disorders that compromise microvessels and specifically the cutaneous vascular system: arterioles, capillaries, postcapill...

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Bibliographic Details
Published in:International journal of lower extremity wounds 2016-03, Vol.15 (1), p.6-16
Main Authors: Papi, Massimo, Papi, Claudia
Format: Article
Language:English
Subjects:
Humans
Skin Diseases, Vascular - diagnosis
Skin Diseases, Vascular - etiology
Skin Diseases, Vascular - therapy
Skin Ulcer - diagnosis
Skin Ulcer - etiology
Skin Ulcer - therapy
Vasculitis - complications
Vasculitis - diagnosis
Vasculitis - therapy
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Summary:Vasculitic ulcers are an emerging problem in wound care that needs to be well defined and adequately approached by caregivers. Cutaneous vasculitis includes several inflammatory disorders that compromise microvessels and specifically the cutaneous vascular system: arterioles, capillaries, postcapillary venules. The pathogenetic role of circulating immunocomplexes and autoantibodies (antineutrophil antibodies) in these diseases has been widely demonstrated in animal models and in humans. Vasculitis can be limited to the skin or represent the cutaneous signs in case of systemic vasculitis with visceral involvement. The injury of cutaneous microvessels may result in impairment of blood flow and consequent focal ischemia and formation of skin ulcers. The ulcers are often multiple and localized on the lower leg and foot where the microcirculatory anatomy and rheologic dynamics are predisposing factors. Approximately 3% to 5% of skin ulcers may be caused by a vasculitic disorder.
ISSN:1534-7346
1552-6941
DOI:10.1177/1534734615621220