Towards protein-based viral mimetics for cancer therapies

Highlights • Current cancer chemotherapy results in high-grade toxicities that limit applicability. • Targeting drugs to tumor cells alleviates toxicity and promotes high local doses. • Cell targeted, virus-like drug nanocarriers escape renal filtration. • Insights into protein self-assembling allow...

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Bibliographic Details
Published in:Trends in biotechnology (Regular ed.) 2015-05, Vol.33 (5), p.253-258
Main Authors: Unzueta, Ugutz, Céspedes, María Virtudes, Vázquez, Esther, Ferrer-Miralles, Neus, Mangues, Ramón, Villaverde, Antonio
Format: Article
Language:English
Subjects:
Architectural engineering
biomaterials
Biomimetic Materials - pharmacokinetics
Biomimetic Materials - therapeutic use
Biomimetics
Breast cancer
Cancer
Cancer therapies
Cytotoxicity
Deoxyribonucleic acid
DNA
DNA damage
Drug Carriers - pharmacokinetics
Drug Carriers - therapeutic use
drug delivery
Drug delivery systems
Drug Delivery Systems - methods
Drug dosages
Drugs
Epidermal growth factor
Humans
Internal Medicine
Molecular weight
Mortality
Nanomedicine - trends
Nanoparticles
Nanoparticles - therapeutic use
Nanostructure
Neoplasms - drug therapy
Passengers
Peptides
Polyethylene glycol
protein engineering
protein nanoparticles
Proteins
Rodents
targeted therapy
Therapy
Toxicity
Tumors
Virus Physiological Phenomena
Viruses
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Summary:Highlights • Current cancer chemotherapy results in high-grade toxicities that limit applicability. • Targeting drugs to tumor cells alleviates toxicity and promotes high local doses. • Cell targeted, virus-like drug nanocarriers escape renal filtration. • Insights into protein self-assembling allow the generation of drug-loadable viral mimetics. • The structural and functional versatility of proteins makes them ideal drug nanocarriers.
ISSN:0167-7799
1879-3096
DOI:10.1016/j.tibtech.2015.02.007