Silver(I) complexes of N-methylbenzothiazole-2-thione: Synthesis, structures and antibacterial activity

Three silver(I) complexes containing N-methylbenzothiazole-2-thione (mbtt) have been prepared and structurally characterized by X-ray single-crystal analysis. Silver(I) nitrate, and silver(I) triflate react with mbtt to give homoleptic complexes of formula [(mbtt)2Ag(μ-mbtt)2Ag(mbtt)2](NO3)2 (1) and...

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Bibliographic Details
Published in:Materials Science & Engineering C 2015-05, Vol.50, p.187-193
Main Authors: Aslanidis, P., Hatzidimitriou, A.G., Andreadou, E.G., Pantazaki, A.A., Voulgarakis, N.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antiinfectives and antibacterials
Antimicrobial activity
Bacteria
Benzothiazoles - chemical synthesis
Benzothiazoles - chemistry
Benzothiazoles - pharmacology
Bonding
Chlorides
Coordination Complexes - chemical synthesis
Coordination Complexes - chemistry
Coordination Complexes - pharmacology
Crystal structures
Crystallography, X-Ray
Escherichia coli - drug effects
Ligands
Microbial Sensitivity Tests
Molecular Conformation
N-methylbenzothiazole-2-thione
Nitrates
Silver - pharmacology
Silver(I)
Strain
Superoxides - metabolism
X-rays
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Summary:Three silver(I) complexes containing N-methylbenzothiazole-2-thione (mbtt) have been prepared and structurally characterized by X-ray single-crystal analysis. Silver(I) nitrate, and silver(I) triflate react with mbtt to give homoleptic complexes of formula [(mbtt)2Ag(μ-mbtt)2Ag(mbtt)2](NO3)2 (1) and [Ag(mbtt)3](CF3SO3) (2) respectively, while silver(I) chloride gives the binuclear halide-bridged [(mbtt)2Ag(μ2-Cl)2Ag(mbtt)2] (3). In the binuclear complex 1 the two metal ions, separated by 3.73Å from each other, are doubly bridged by the exocyclic S-atoms of two mbtt ligands, with the tetrahedral environment around each silver ion being completed by the S-atoms of two terminally bonded mbtt units. Compound 2 is mononuclear with the metal ion surrounded by the exocyclic S-atoms of three mbtt ligands in a nearly ideal trigonal planar arrangement. The new complexes showed significant in vitro antibacterial activity against certain Gram-positive and Gram-negative bacterial strains.
ISSN:0928-4931
1873-0191
DOI:10.1016/j.msec.2015.02.014