Silver(I) complexes of N-methylbenzothiazole-2-thione: Synthesis, structures and antibacterial activity

• Published in: Materials Science & Engineering C 2015-05, Vol.50, p.187-193
• Main Authors: Aslanidis, P., Hatzidimitriou, A.G., Andreadou, E.G., Pantazaki, A.A., Voulgarakis, N.
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antiinfectives and antibacterials; Antimicrobial activity; Bacteria; Benzothiazoles - chemical synthesis; Benzothiazoles - chemistry; Benzothiazoles - pharmacology; Bonding; Chlorides; Coordination Complexes - chemical synthesis; Coordination Complexes - chemistry; Coordination Complexes - pharmacology; Crystal structures; Crystallography, X-Ray; Escherichia coli - drug effects; Ligands; Microbial Sensitivity Tests; Molecular Conformation; N-methylbenzothiazole-2-thione; Nitrates; Silver - pharmacology; Silver(I); Strain; Superoxides - metabolism; X-rays
• ISSN: 0928-4931; 1873-0191
• DOI: 10.1016/j.msec.2015.02.014

Three silver(I) complexes containing N-methylbenzothiazole-2-thione (mbtt) have been prepared and structurally characterized by X-ray single-crystal analysis. Silver(I) nitrate, and silver(I) triflate react with mbtt to give homoleptic complexes of formula [(mbtt)2Ag(μ-mbtt)2Ag(mbtt)2](NO3)2 (1) and [Ag(mbtt)3](CF3SO3) (2) respectively, while silver(I) chloride gives the binuclear halide-bridged [(mbtt)2Ag(μ2-Cl)2Ag(mbtt)2] (3). In the binuclear complex 1 the two metal ions, separated by 3.73Å from each other, are doubly bridged by the exocyclic S-atoms of two mbtt ligands, with the tetrahedral environment around each silver ion being completed by the S-atoms of two terminally bonded mbtt units. Compound 2 is mononuclear with the metal ion surrounded by the exocyclic S-atoms of three mbtt ligands in a nearly ideal trigonal planar arrangement. The new complexes showed significant in vitro antibacterial activity against certain Gram-positive and Gram-negative bacterial strains.