Air pollution and cytokine responsiveness in asthmatic and non-asthmatic children

Epidemiological studies indicate that asthmatic children are more susceptible to traffic-related air pollution exposure than non-asthmatic children. Local and systemic inflammation in combination with oxidative stress have been suggested as a possible susceptibility factor. We investigated effect mo...

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Bibliographic Details
Published in:Environmental research 2015-04, Vol.138, p.381-390
Main Authors: Klümper, Claudia, Krämer, Ursula, Lehmann, Irina, von Berg, Andrea, Berdel, Dietrich, Herberth, Gunda, Beckmann, Christina, Link, Elke, Heinrich, Joachim, Hoffmann, Barbara, Schins, Roel P.F.
Format: Article
Language:English
Subjects:
Air Pollutants - blood
Air pollution
Asthma
Asthma - chemically induced
Asthma - epidemiology
Blood
Child
Children
Cohort Studies
Cytokines
Cytokines - metabolism
Environmental Exposure
Environmental Monitoring
Exposure
Female
Flow Cytometry
Germany - epidemiology
Humans
Inflammatory markers
Male
Models, Theoretical
Nitrogen dioxide
Nitrogen Oxides - blood
Particle Size
Particulate Matter - blood
Regression
Vehicle Emissions - analysis
Whole blood assay
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Summary:Epidemiological studies indicate that asthmatic children are more susceptible to traffic-related air pollution exposure than non-asthmatic children. Local and systemic inflammation in combination with oxidative stress have been suggested as a possible susceptibility factor. We investigated effect modification by asthma status for the association between air pollution exposure and systemic effects using whole blood cytokine responsiveness as an inflammatory marker. The study was nested within the two German birth cohort studies GINIplus and LISAplus and initially designed as a random sub-sample enriched with asthmatic children. Using data from 27 asthmatic and 59 non-asthmatic six-year-old children we measured the production of Interleukin-6 (IL)-6, IL-8, IL-10, monocyte chemotactic protein-1 (MCP-1), tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) in whole blood after ex-vivo stimulation with urban particulate matter (EHC-93). Air pollution exposure (nitrogen dioxide (NO2), nitrogen oxides (NOx), particulate matter with an aerodynamic diameter
ISSN:0013-9351
1096-0953
DOI:10.1016/j.envres.2015.02.034