Evaluation of Stability of Mesoporous Silica Nanoparticles and Their Further Formulation in Tablet Form

Mesoporous silica nanoparticles have been widely investigated as drug delivery systems. The present study evaluated physical stability of indomethacin loaded mesoporous MCM-41 nanoparticles. The size, polydispersity index, zeta-potential, and drug loading degree of nanoparticles were determined imme...

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Bibliographic Details
Published in:Journal of dispersion science and technology 2016-01, Vol.37 (1), p.113-118
Main Authors: Yoncheva, Krassimira, Tzankov, Borislav, Popova, Margarita, Petrova, Vladislava, Lambov, Nikolai
Format: Article
Language:English
Subjects:
Compressing
Dispersions
Drying
Formulations
MCM-41
mesoporous silica nanoparticles
Nanoparticles
Silicon dioxide
Stability
tableting
Tablets
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Summary:Mesoporous silica nanoparticles have been widely investigated as drug delivery systems. The present study evaluated physical stability of indomethacin loaded mesoporous MCM-41 nanoparticles. The size, polydispersity index, zeta-potential, and drug loading degree of nanoparticles were determined immediately after their preparation and after 6 months storage at 25°C in dry state. The results showed insignificant changes in these parameters, suggesting high stability of nanoparticles and loaded indomethacin. The nanoparticles were formulated in tablets by direct compression. The low friability indicated good resistance during handling and storage. The formulation of the nanoparticles into tablets decreased the initial release of indomethacin.
ISSN:0193-2691
1532-2351
DOI:10.1080/01932691.2015.1030028