Key technologies for the industrial production of fumaric acid by fermentation

The growing concern about the safety of food and dairy additives and the increasing costs of petroleum-based chemicals have rekindled the interest in the fermentation processes for fumaric acid production. The key problems of the industrial production of microbial fumaric acid are reviewed in this p...

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Bibliographic Details
Published in:Biotechnology advances 2012-11, Vol.30 (6), p.1685-1696
Main Authors: Xu, Qing, Li, Shuang, Huang, He, Wen, Jianping
Format: Article
Language:English
Subjects:
additives
Alternative substrates
Bacteria - metabolism
Biological and medical sciences
Biotechnology
Biotechnology - economics
Biotechnology - methods
Derivatives
Downstream processing
Economics
Fermentation
food safety
Foods
Fumarates - economics
Fumarates - metabolism
Fumaric acid
Fundamental and applied biological sciences. Psychology
Industrial Microbiology - economics
Industrial Microbiology - methods
markets
Metabolic Networks and Pathways
Methods. Procedures. Technologies
Microbial engineering. Fermentation and microbial culture technology
Microorganisms
Morphology control
Process development
Strain improvement
Strategy
value added
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Summary:The growing concern about the safety of food and dairy additives and the increasing costs of petroleum-based chemicals have rekindled the interest in the fermentation processes for fumaric acid production. The key problems of the industrial production of microbial fumaric acid are reviewed in this paper. Various strategies, including strain improvement, morphology control, substrate choice, fermentation process and separation process, are summarized and compared, and their economical possibilities for industrial processes are discussed. The market prospects and technological strategies for value-added fumaric acid derivatives are also addressed. The future prospects of microbial fumaric acid production are proposed at the end of this article. ► The industrialization of microbial fumaric acid production is discussed. ► The state-of-the-art technological achievements in fumaric acid production are reviewed. ► The future prospects on microbial fumaric acid production are proposed.
ISSN:0734-9750
1873-1899
DOI:10.1016/j.biotechadv.2012.08.007