In vitro investigation of ultra-pure Zn and its mini-tube as potential bioabsorbable stent material

In the study, the mechanical properties, degradation behavior and in vitro biocompatibility of an ultra-pure Zn and its mini-tube were evaluated with the high-pure Mg and its mini-tube as controls. Compared with high-pure Mg, ultra-pure Zn had close mechanical properties and cytotoxicity, but it ind...

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Bibliographic Details
Published in:Materials letters 2015-12, Vol.161, p.53-56
Main Authors: Liu, Xiwei, Sun, Jianke, Yang, Yinghong, Pu, Zhongjie, Zheng, Yufeng
Format: Article
Language:English
Subjects:
Biocompatibility
Corrosion rate
Degradation
Erythrocytes
In vitro testing
Mechanical properties
Surgical implants
Tubes
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Summary:In the study, the mechanical properties, degradation behavior and in vitro biocompatibility of an ultra-pure Zn and its mini-tube were evaluated with the high-pure Mg and its mini-tube as controls. Compared with high-pure Mg, ultra-pure Zn had close mechanical properties and cytotoxicity, but it indicated lower corrosion rate (0.011mm/y) than pure Mg in Hank's solution. Meanwhile, the hematolysis rate (1.00%) was lower than 5%, which means that Zn has no significant destructive effect on erythrocyte. Furthermore, compared with plate specimens, the tube specimens showed higher corrosion rate (Zn ~0.028 to 0.037mm/y and Mg ~0.61 to 0.73mm/y, respectively) and hemocompatibility (Zn ~1.19% and Mg ~9.50%, respectively). In conclusion, the ultra-pure Zn mini-tubes might be considered as a potential bioabsorbable stent material.
ISSN:0167-577X
DOI:10.1016/j.matlet.2015.06.107