Pulsed electric field-induced remote decapsulation of nanocomposite liposomes with implanted conducting nanoparticles

The results obtained in creating the new nanocomposite hybrid systems sensitive to external nonthermal electric-field pulses, which are created for the encapsulation, addressed delivery, and the controlled decapsulation of various substances in aqueous media, are presented. Such systems are based on...

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Bibliographic Details
Published in:Journal of communications technology & electronics 2015-10, Vol.60 (10), p.1097-1108
Main Authors: Gulyaev, Yu. V., Cherepenin, V. A., Vdovin, V. A., Taranov, I. V., Yaroslavov, A. A., Kim, V. P., Khomutov, G. B.
Format: Article
Language:English
Subjects:
Applications of Radiotechnology and Electronics in Biology and Medicine
Atomic force microscopy
Communications Engineering
Communications technology
Conduction
Construction
Electric fields
Engineering
Hybrid control systems
Investigations
Lipids
Liposomes
Magnetic fields
Mathematical models
Medical research
Microscopy
Nanocomposites
Nanoparticles
Nanostructure
Networks
Polymers
Studies
Toxicity
Transmission electron microscopy
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Summary:The results obtained in creating the new nanocomposite hybrid systems sensitive to external nonthermal electric-field pulses, which are created for the encapsulation, addressed delivery, and the controlled decapsulation of various substances in aqueous media, are presented. Such systems are based on liposomes containing electrically neutral biogenic lipids that are functionalized by conducting nanoparticles and polymers. The fabricated systems have been investigated using transmission electron microscopy, atomic-force microscopy, electron magnetic resonance, laser light scattering, electrophoresis, and conductometry. The systems constructed under the action of short (on the order of 8 ns) electric pulses with high intensities (up to 100 kV/m) are found to exhibit the remote decapsulation effect. The model describing the mechanism of interaction between nanostructured liposomes with surface conducting nanoparticles and an external electric field leading to substantial changes in liposome structure is proposed. The critical values of the external electric field stimulating the decapsulation of nanocomposite liposomes are estimated with the help of the constructed model.
ISSN:1064-2269
1555-6557
DOI:10.1134/S1064226915100034