Silicon nanowire-based therapeutic agents for in vivotumor near-infrared photothermal ablation

The first example of silicon nanowire (SiNW)-based in vivotumor phototherapy is presented. Gold nanoparticle (AuNP)-decorated SiNWs are employed as high-performance NIR hyperthermia agents for highly efficacious in vivotumour ablation. Significantly, the overall survival time of SiNW-treated mice is...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2014-04, Vol.2 (19), p.2892-2898
Main Authors: Su, Yuanyuan, Peng, Fei, Ji, Xiaoyuan, Lu, Yimei, Wei, Xinpan, Chu, Binbin, Song, Chongxi, Zhou, Yanfeng, Jiang, Xiangxu, Zhong, Yiling, Lee, Shuit-Tong, He, Yao
Format: Article
Language:English
Subjects:
Ablation
Biology
Effectiveness
Hyperthermia
Mice
Nanostructure
Nanowires
Silicon
Survival
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Summary:The first example of silicon nanowire (SiNW)-based in vivotumor phototherapy is presented. Gold nanoparticle (AuNP)-decorated SiNWs are employed as high-performance NIR hyperthermia agents for highly efficacious in vivotumour ablation. Significantly, the overall survival time of SiNW-treated mice is drastically prolonged, with 100% of mice being alive and tumor-free for over 8 months, which is the longest survival time ever reported for tumor-bearing mice treated with nanomaterial-based NIR hyperthermia agents.
ISSN:2050-750X
2050-7518
DOI:10.1039/c4tb00100a