Alteration of Membrane Compositional Asymmetry by LiCoO sub(2) Nanosheets

Given the projected massive presence of redox-active nanomaterials in the next generation of consumer electronics and electric vehicle batteries, they are likely to eventually come in contact with cell membranes, with biological consequences that are currently not known. Here, we present nonlinear o...

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Bibliographic Details
Published in:ACS nano 2015-09, Vol.9 (9), p.8755-8765
Main Authors: Doganguen, Merve, Hang, Mimi N, Troiano, Julianne M, McGeachy, Alicia C, Melby, Eric S, Pedersen, Joel A, Hamers, Robert J, Geiger, Franz M
Format: Article
Language:English
Subjects:
Alterations
Asymmetry
Biological
Electronics
Lipids
Mathematical models
Membranes
Nanostructure
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Summary:Given the projected massive presence of redox-active nanomaterials in the next generation of consumer electronics and electric vehicle batteries, they are likely to eventually come in contact with cell membranes, with biological consequences that are currently not known. Here, we present nonlinear optical studies showing that lithium nickel manganese cobalt oxide nanosheets carrying a negative zeta -potential have no discernible consequences for lipid alignment and interleaflet composition in supported lipid bilayers formed from zwitterionic and negatively charged lipids. In contrast, lithiated and delithiated LiCoO sub(2) nanosheets having positive and neutral zeta -potentials, respectively, alter the compositional asymmetry of the two membrane leaflets, and bilayer asymmetry remains disturbed even after rinsing. The insight that some cobalt oxide nanoformulations induce alterations to the compositional asymmetry in idealized model membranes may represent an important step toward assessing the biological consequences of their predicted widespread use. Keywords: phospholipid bilayer asymmetry; nano-bio interface; sum-frequency generation; secondary ion mass spectrometry; transbilayer movement; silica/water interfaces
ISSN:1936-0851
1936-086X
DOI:10.1021/acsnano.5b01440